Fluindione

Names

[ CAS No. ]:
957-56-2

[ Name ]:
Fluindione

[Synonym ]:
2-(4-Fluor-phenyl)-indandion-(1,3)
1H-Indene-1,3(2H)-dione,2-(4-fluorophenyl)
Fluindione
Fluindionum [INN-Latin]
Fluindione [INN]
2-(4-fluoro-phenyl)-indan-1,3-dione
2-(p-Fluorophenyl)-1,3-indandione
Previscan
Fluindiona [INN-Spanish]
LM 123
2-(4-Fluor-phenyl)-indan-1,3-dion
2-(4-fluorophenyl)-1,3-indanedione

Biological Activity

[Description]:

Fluindione is a inhibitor of 5-lipoxygenase with the IC50 of 15 μM. Fluindione has antiinflammatory activity[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[References]

[1]. Brooks, et al. Structural analysis of 2-aryl-1,3-dione compounds as inhibitors of 5-lipoxygenase. Bioorganic & Medicinal Chemistry Letters, 2(10), 1309–1314.

Chemical & Physical Properties

[ Density]:
1.335g/cm3

[ Boiling Point ]:
406.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₅H₉FO₂

[ Molecular Weight ]:
240.23

[ Flash Point ]:
154.5ºC

[ Exact Mass ]:
240.05900

[ PSA ]:
34.14000

[ LogP ]:
2.98850

[ Index of Refraction ]:
1.619

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK5700000

CHEMICAL NAME :: 1,3-Indandione, 2-(p-fluorophenyl)-

CAS REGISTRY NUMBER :: 957-56-2

BEILSTEIN REFERENCE NO. :: 2052411

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H9-F-O2

MOLECULAR WEIGHT :: 240.24

WISWESSER LINE NOTATION :: L56 BV DV CHJ CR DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 17,497,1967

Safety Information

[ RIDADR ]:
UN 2811

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%