Biotin-PEG9-amine

Names

[ CAS No. ]:
960132-48-3

[ Name ]:
Biotin-PEG9-amine

[Synonym ]:
MFCD08274600

Biological Activity

[Description]:

Biotin-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₅₈N₄O₁₁S

[ Molecular Weight ]:
682.86700

[ Exact Mass ]:
682.38200

[ PSA ]:
211.60000

[ LogP ]:
1.44590

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport