5β-Pregnan-3α-ol-20-one-17α,21,21,21-d4

Names

[ CAS No. ]:
96737-93-8

[ Name ]:
5β-Pregnan-3α-ol-20-one-17α,21,21,21-d4

[Synonym ]:
5β-PREGNAN-3α-OL-20-ONE-17α,21,21,21-D4

Biological Activity

[Description]:

5β-Pregnan-3α-ol-20-one-17α,21,21,21-d4 is the deuterium labeled Pregnanolone. Pregnanolone (Eltanolone), a Progesterone metabolite, is a neurosteroid. Pregnanolone is a GABAA receptor positive allosteric modulator. Pregnanolone has anxiolytic and antidepressant effects[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Tereza Smejkalova, et al. Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms. Br J Pharmacol. 2021 Oct;178(19):3888-3904.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H34O2

[ Molecular Weight ]:
318.49300

[ Exact Mass ]:
318.25600

[ PSA ]:
37.30000

[ LogP ]:
4.59520

Related Compounds