Xanthine amine congener

Names

[ Name ]:
Xanthine amine congener

[Synonym ]:
Papaxac
XAC
Lopac-X-103
xanthine amine congener
Xanthine amine congener xac

Biological Activity

[Description]:

Xanthine amine congener is a non-selective adenosine receptor antagonist[1]. Xanthine amine congener induces convulsions in mice[2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[References]

[1]. Ukena D, et al. Functionalized congeners of 1,3-dipropyl-8-phenylxanthine: potent antagonists for adenosine receptors that modulate membrane adenylate cyclase in pheochromocytoma cells, platelets and fat cells. Life Sci. 1986 Mar 3;38(9):797-807.

Chemical & Physical Properties

[ Density]:
1.262g/cm3

[ Molecular Formula ]:
C₂₁H₂₈N₆O₄

[ Molecular Weight ]:
428.48

[ Exact Mass ]:
428.21700

[ PSA ]:
137.03000

[ LogP ]:
1.91820

[ Index of Refraction ]:
1.586

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Chaperoning of the A1-adenosine receptor by endogenous adenosine - an extension of the retaliatory metabolite concept.

Mol. Pharmacol. 87(1) , 39-51, (2015)

Cell-permeable orthosteric ligands can assist folding of G protein-coupled receptors in the endoplasmic reticulum (ER); this pharmacochaperoning translates into increased cell surface levels of recept...

Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics.

FASEB J. 25(10) , 3465-76, (2011)

A growing awareness indicates that many G-protein-coupled receptors (GPCRs) exist as homodimers, but the extent of the cooperativity across the dimer interface has been largely unexplored. Here, measu...

Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease.

Neurobiol. Dis. 74 , 41-57, (2015)

Stimulation of dopamine D1 receptor (D1R) and adenosine A2A receptor (A2AR) increases cAMP-dependent protein kinase (PKA) activity in the brain. In Huntington's disease, by essentially unknown mechani...