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α-Hydroxytamoxifen

Names

[ CAS No. ]:
97151-02-5

[ Name ]:
α-Hydroxytamoxifen

[Synonym ]:
trans-(E)-4-[4-(2-dimethylamino-ethoxy)-phenyl]-3,4-diphenyl-but-3-en-2-ol
(E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-buten-3-ol
Trans-Hydroxy-Tamoxifen
(E)-|A-Hydroxy Tamoxifen

Biological Activity

[Description]:

α-Hydroxytamoxifen is a metabolite of tamoxifen, reacts with DNA in the absence of metabolizing enzymes, and causes formation of DNA adducts[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Phillips DH, et al. alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes. Cancer Res. 1994 Nov 1;54(21):5518-22.

Chemical & Physical Properties

[ Density]:
1.094g/cm3

[ Boiling Point ]:
533.8ºC at 760 mmHg

[ Melting Point ]:
115-119ºC

[ Molecular Formula ]:
C26H29NO2

[ Molecular Weight ]:
387.51400

[ Flash Point ]:
276.6ºC

[ Exact Mass ]:
387.22000

[ PSA ]:
32.70000

[ LogP ]:
5.70170

[ Index of Refraction ]:
1.595

Safety Information

[ HS Code ]:
2922509090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%


Related Compounds