Desmethylcitalopram (hydrochloride)

Names

[ CAS No. ]:
97743-99-2

[ Name ]:
Desmethylcitalopram (hydrochloride)

[Synonym ]:
UNII-461OE8B9GL
rac Desmethyl Citalopram Hydrochloride

Biological Activity

[Description]:

Desmethylcitalopram (DCIT) hydrochloride is the active metabolite of Citalopram (HY-121203). Desmethylcitalopram has antidepressant effects. Desmethylcitalopram also inhibits cytochrome P450-2D6, -2C19 with IC50s of 39.5 and 53.5 μM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Research Areas >> Neurological Disease

[References]

[1]. von Moltke LL, et aI. Citalopram and desmethylcitalopram in vitro: human cytochromes mediating transformation, and cytochrome inhibitory effects. Biol Psychiatry. 1999 Sep 15;46(6):839-49.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H20ClFN2O

[ Molecular Weight ]:
346.82600

[ Exact Mass ]:
346.12500

[ PSA ]:
45.05000

[ LogP ]:
4.66368

Related Compounds