3,4'-Dihydroxy-3',5,7-trimethoxyflavan

Names

[ Name ]:
3,4'-Dihydroxy-3',5,7-trimethoxyflavan

[Synonym ]:
2H-1-Benzopyran-3-ol, 3,4-dihydro-2-(4-hydroxy-3-methoxyphenyl)-5,7-dimethoxy-
2-(4-Hydroxy-3-methoxyphenyl)-5,7-dimethoxy-3-chromanol

Biological Activity

[Description]:

5,7,3' -tri-O-Methyl (-)-epicatechin (Compound 13) is a phospholipase Cγ1 (PLCγ1) inhibitor. 5,7,3' -tri-o-methyl (-)-epicatechin has a methylene dioxy benzene ring and can express inhibitory activity against PLCγ1. 5,7,3' -tri-O-Methyl (-)-epicatechin can be used in the study of chemotherapy and chemopexic agents for cancer [1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Lee JS, et al. Inhibition of phospholipase Cgamma1 and cancer cell proliferation by lignans and flavans from Machilus thunbergii. Arch Pharm Res. 2004 Oct;27(10):1043-7

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
541.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₀O₆

[ Molecular Weight ]:
332.35

[ Flash Point ]:
281.0±30.1 °C

[ Exact Mass ]:
332.125977

[ PSA ]:
77.38000

[ LogP ]:
1.49

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.595

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2932999099

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%