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Ganoderic acid F

Names

[ CAS No. ]:
98665-15-7

[ Name ]:
Ganoderic acid F

[Synonym ]:
Lanost-8-en-26-oic acid, 12-(acetyloxy)-3,7,11,15,23-pentaoxo-, (12β)-
UNII:CLQ52DLW7V
(12β)-12-Acetoxy-3,7,11,15,23-pentaoxolanost-8-en-26-oic acid
MFCD09264655
Ganoderic acid F

Biological Activity

[Description]:

Ganoderic acid F is a ganoderic acid. Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium signaling, and endoplasmic reticulum stress[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Ganoderic acid F (48 hours) inhibits the proliferation of HeLa human cervical carcinoma cells with an IC50 value of 19.5 μM[2].

[References]

[1]. Teekachunhatean S, et al. Pharmacokinetics of ganoderic acids a and f after oral administration of ling zhi preparation in healthy male volunteers. Evid Based Complement Alternat Med. 2012;2012:780892.

[2]. Yue QX, et al. Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells. Phytomedicine. 2010 Jul;17(8-9):606-13.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
709.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C32H42O9

[ Molecular Weight ]:
570.670

[ Flash Point ]:
222.9±26.4 °C

[ Exact Mass ]:
570.282898

[ LogP ]:
2.93

[ Vapour Pressure ]:
0.0±4.9 mmHg at 25°C

[ Index of Refraction ]:
1.553

[ Water Solubility ]:
Insuluble (6.8E-4 g/L) (25 ºC)

Related Compounds