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Kushenol B

Names

[ CAS No. ]:
99217-64-8

[ Name ]:
Kushenol B

[Synonym ]:
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)-
(2S)-2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-8-[(2R)-2-isopropenyl-5-methyl-4-hexen-1-yl]-6-(3-methyl-2-buten-1-yl)-2,3-dihydro-4H-chromen-4-one

Biological Activity

[Description]:

Kushenol B is an isoprenoid flavonoid isolated from S. flavescens, has antimicrobial, anti-inflammatory and antioxidant activities[1]. Kushenol B has inhibitory activity against cAMP phosphodiesterase (PDE), with an IC50 of 31 µM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Infection
Research Areas >> Inflammation/Immunology

[Target]

IC50: 31 µM (cAMP PDE)[1]


[References]

[1]. Han-Tian Fan, et al. The rational search for PDE10A inhibitors from Sophora flavescens roots using pharmacophore‑ and docking‑based virtual screening. Mol Med Rep

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
702.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H36O6

[ Molecular Weight ]:
492.603

[ Flash Point ]:
228.2±26.4 °C

[ Exact Mass ]:
492.251190

[ LogP ]:
8.61

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.605

Related Compounds