neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-

Modify Date: 2024-01-06 19:45:47

neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)- structure	Common Name	neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-
	CAS Number	126050-12-2	Molecular Weight	1109.238
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₅₇H₆₈N₁₄O₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-

MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively[1][2].

Name	[TYR5,D-TRP6,8,9, ARG10]-NEUROKININ A(4-10)
Synonym	More Synonyms

Description	MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	Tachykinin NK2 Receptor:7.9 (pA2) NK1:5.2 (pA2) NK3:4.9 (pA2)
In Vitro	In competitive radioligand binding assays, MEN 10207 (the IC50 ranges of 21-54 nM) has high affinity in bovine stomach membranes and SKLKB82#3 cells, a murine fibroblast cell line transfected with a cDNA encoding for the bovine NK2 receptor[3].
In Vivo	but not Substance P in a dose-dependent manner. And MEN 10207 also effectively blocks the long-term reflex facilitation to the gastrocnemius nerve stimulation[1]. Animal Model: Decerebrate, spinalized, unanesthetized Female Sprague-Dawley rats (250-280 g)[1] Dosage: 7 pmol/10 μL, 70 pmol/10 μL, 700 pmol/10 μL Administration: Intrathecal administration; once Result: Blocked the reflex facilitation to intrathecal Neurokinin A, but not Substance P in a dose-dependent manner.
References	[1]. X J Xu, et al. On the role of NK-2 tachykinin receptors in the mediation of spinal reflex excitability in the rat. Neuroscience. 1991;44(2):483-90. [2]. P Rovero, et al. A highly selective NK-2 tachykinin receptor antagonist containing D-tryptophan. Eur J Pharmacol. 1990 Jan 3;175(1):113-5. [3]. A K Henderson, et al. Demonstration of a neurokinin A receptor subtype in transfected fibroblasts. Eur J Pharmacol. 1992 Feb 13;225(2):175-8.

Density	1.5±0.1 g/cm3
Molecular Formula	C₅₇H₆₈N₁₄O₁₀
Molecular Weight	1109.238
Exact Mass	1108.524292
LogP	3.11
Index of Refraction	1.711

neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-

5-Tyr-6,8,9-Trp-10-Arg-NKA (4-10)

5-Tyr-6,8,9-Trp-10-Arg-neurokinin A (4-10)

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)- suppliers

neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)- price

neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-

Use of neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-

Names

Biological Activity

Chemical & Physical Properties

Synonyms