Z-Gly-Pro-Phe-Leu-CHO

Modify Date: 2024-01-12 14:03:41

Z-Gly-Pro-Phe-Leu-CHO Structure
Z-Gly-Pro-Phe-Leu-CHO structure
Common Name Z-Gly-Pro-Phe-Leu-CHO
CAS Number 159659-05-9 Molecular Weight 550.65
Density N/A Boiling Point N/A
Molecular Formula C30H38N4O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Z-Gly-Pro-Phe-Leu-CHO


Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity)[1].

 Names

Name Z-Gly-Pro-Phe-Leu-CHO

 Z-Gly-Pro-Phe-Leu-CHO Biological Activity

Description Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity)[1].
Related Catalog
References

[1]. M Orlowski, et al. Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes). Biochemistry. 1997 Nov 11;36(45):13946-53.  

 Chemical & Physical Properties

Molecular Formula C30H38N4O6
Molecular Weight 550.65
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