MC-GGFG-AM-(10Me-11F-Camptothecin)
Modify Date: 2024-01-03 13:43:25
MC-GGFG-AM-(10Me-11F-Camptothecin) structure
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Common Name | MC-GGFG-AM-(10Me-11F-Camptothecin) | ||
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| CAS Number | 2873460-70-7 | Molecular Weight | 1038.04 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C51H56FN9O14 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MC-GGFG-AM-(10Me-11F-Camptothecin)MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells[1]. |
| Name | MC-GGFG-AM-(10Me-11F-Camptothecin) |
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| Description | MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells[1]. |
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| Related Catalog | |
| Target |
Topoisomerase I |
| References |
| Molecular Formula | C51H56FN9O14 |
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| Molecular Weight | 1038.04 |