melarsoprol

Modify Date: 2024-01-02 08:57:15

melarsoprol Structure
melarsoprol structure
Common Name melarsoprol
CAS Number 494-79-1 Molecular Weight 398.33900
Density N/A Boiling Point 688.4ºC at 760 mmHg
Molecular Formula C12H15AsN6OS2 Melting Point N/A
MSDS N/A Flash Point 370.2ºC

 Use of melarsoprol


Melarsoprol (Arsobal), a melaminophenylarsine-type trivalent organic arsenical, is an important drug for African trypanosomiasis. Melarsoprol is also active against leukemia cell lines and plasma cells from myeloma patients. Melarsoprol increases the biliary output of GSH in rats[1].

 Names

Name [2-[4-[(4,6-diamino-1,3,5-triazin-2-yl)amino]phenyl]-1,3,2-dithiarsolan-4-yl]methanol
Synonym More Synonyms

 melarsoprol Biological Activity

Description Melarsoprol (Arsobal), a melaminophenylarsine-type trivalent organic arsenical, is an important drug for African trypanosomiasis. Melarsoprol is also active against leukemia cell lines and plasma cells from myeloma patients. Melarsoprol increases the biliary output of GSH in rats[1].
Related Catalog
References

[1]. Z Gregus, et al. Role of glutathione in the biliary excretion of the arsenical drugs trimelarsan and melarsoprol. Biochem Pharmacol. 2000 Jun 1;59(11):1375-85.  

 Chemical & Physical Properties

Boiling Point 688.4ºC at 760 mmHg
Molecular Formula C12H15AsN6OS2
Molecular Weight 398.33900
Flash Point 370.2ºC
Exact Mass 397.99600
PSA 173.57000
LogP 1.55110
Vapour Pressure 6.7E-20mmHg at 25°C

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

Mel B
melarsenoxide-BAL
Melarsoprol
Melarsoprolum [INN-Latin]
Melarsoprolum
2-(p-(4,6-Diamino-s-triazin-2-ylamino)phenyl)-1,3,2-dithiarsolane-4-methanol
{2-[4-(4,6-diamino-[1,3,5]triazin-2-ylamino)-phenyl]-[1,3,2]dithiarsolan-4-yl}-methanol
EINECS 207-793-4
Melarsenoxid-BAL
1,3,2-Dithiarsolane-4-methanol,2-(4-((4,6-diamino-1,3,5-triazin-2-yl)amino)phenyl)
Arsobal
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