四甲基-1,4-苯醌结构式
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常用名 | 四甲基-1,4-苯醌 | 英文名 | DUROQUINONE |
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| CAS号 | 527-17-3 | 分子量 | 164.20100 | |
| 密度 | 1.039 g/cm3 | 沸点 | 230.1ºC at 760 mmHg | |
| 分子式 | C10H12O2 | 熔点 | 110-112 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 83.6ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Quinone-induced protein handling changes: implications for major protein handling systems in quinone-mediated toxicity.
Toxicol. Appl. Pharmacol. 280(2) , 285-95, (2014) Para-quinones such as 1,4-Benzoquinone (BQ) and menadione (MD) and ortho-quinones including the oxidation products of catecholamines, are derived from xenobiotics as well as endogenous molecules. The effects of quinones on major protein handling systems in ce... |
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Method development in quantitative NMR towards metrologically traceable organic certified reference materials used as (31)P qNMR standards.
Anal. Bioanal. Chem 407 , 3115-3123, (2015) Quantitative nuclear magnetic resonance (qNMR) spectroscopy is employed by an increasing number of analytical and industrial laboratories for the assignment of content and quantitative determination of impurities. Within the last few years, it was demonstrate... |
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Using high-performance ¹H NMR (HP-qNMR®) for the certification of organic reference materials under accreditation guidelines--describing the overall process with focus on homogeneity and stability assessment.
J. Pharm. Biomed. Anal. 93 , 102-110, (2014) Quantitative NMR spectroscopy (qNMR) is gaining interest across both analytical and industrial research applications and has become an essential tool for the content assignment and quantitative determination of impurities. The key benefits of using qNMR as me... |
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Effect of chronic hyperoxic exposure on duroquinone reduction in adult rat lungs.
Am. J. Physiol. Lung Cell. Mol. Physiol. 289(5) , L788-97, (2005) NAD(P)H:quinone oxidoreductase 1 (NQO1) plays a dominant role in the reduction of the quinone compound 2,3,5,6-tetramethyl-1,4-benzoquinone (duroquinone, DQ) to durohydroquinone (DQH2) on passage through the rat lung. Exposure of adult rats to 85% O2 for > or... |
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Duroquinone reduction during passage through the pulmonary circulation.
Am. J. Physiol. Lung Cell. Mol. Physiol. 285(5) , L1116-31, (2003) The lungs can substantially influence the redox status of redox-active plasma constituents. Our objective was to examine aspects of the kinetics and mechanisms that determine pulmonary disposition of redox-active compounds during passage through the pulmonary... |
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Evidence for two different electron transfer pathways in the same enzyme, nitrate reductase A from Escherichia coli.
Eur. J. Biochem. 271(12) , 2400-7, (2004) In order to clarify the role of cytochrome in nitrate reductase we have performed spectrophotometric and stopped-flow kinetic studies of reduction and oxidation of the cytochrome hemes with analogues of physiological quinones, using menadione as an analogue o... |
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Role of mitochondrial electron transport complex I in coenzyme Q1 reduction by intact pulmonary arterial endothelial cells and the effect of hyperoxia.
Am. J. Physiol. Lung Cell. Mol. Physiol. 293(3) , L809-19, (2007) The objective was to determine the impact of intact normoxic and hyperoxia-exposed (95% O(2) for 48 h) bovine pulmonary arterial endothelial cells in culture on the redox status of the coenzyme Q(10) homolog coenzyme Q(1) (CoQ(1)). When CoQ(1) (50 microM) was... |
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Genome-wide transcriptome profiling of region-specific vulnerability to oxidative stress in the hippocampus.
Genomics 90(2) , 201-12, (2007) Neurons in the hippocampal CA1 region are particularly sensitive to oxidative stress (OS), whereas those in CA3 are resistant. To uncover mechanisms for selective CA1 vulnerability to OS, we treated organotypic hippocampal slices with duroquinone and compared... |
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Influence of pulmonary arterial endothelial cells on quinone redox status: effect of hyperoxia-induced NAD(P)H:quinone oxidoreductase 1.
Am. J. Physiol. Lung Cell. Mol. Physiol. 290(3) , L607-19, (2006) The objective of this study was to examine the impact of chronic hyperoxic exposure (95% O2 for 48 h) on intact bovine pulmonary arterial endothelial cell redox metabolism of 2,3,5,6-tetramethyl-1,4-benzoquinone (duroquinone, DQ). DQ or durohydroquinone (DQH2... |
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Impact of pulmonary arterial endothelial cells on duroquinone redox status.
Free Radic. Biol. Med. 37(1) , 86-103, (2004) The study objective was to use pulmonary arterial endothelial cells to examine kinetics and mechanisms contributing to the disposition of the quinone 2,3,5,6-tetramethyl-1,4-benzoquinone (duroquinone, DQ) observed during passage through the pulmonary circulat... |