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O2−O2 and O2−N2 collision-induced absorption mechanisms unravelled
10.1038/s41557-018-0015-x 2018-04-09 Collision-induced absorption is the phenomenon in which interactions between colliding molecules lead to absorption of light, even for transitions that are forbidden for the isolated molecules. Collision-induced absorption contributes to the atmospheric heat ... |
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A [4Fe–4S]-Fe(CO)(CN)-l-cysteine intermediate is the first organometallic precursor in [FeFe] hydrogenase H-cluster bioassembly
10.1038/s41557-018-0026-7 2018-04-09 Biosynthesis of the [FeFe] hydrogenase active site (the 'H-cluster') requires the interplay of multiple proteins and small molecules. Among them, the radical S-adenosylmethionine enzyme HydG, a tyrosine lyase, has been proposed to generate a complex that cont... |
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High phase-purity 1T′-MoS2- and 1T′-MoSe2-layered crystals
10.1038/s41557-018-0035-6 2018-04-02 Phase control plays an important role in the precise synthesis of inorganic materials, as the phase structure has a profound influence on properties such as conductivity and chemical stability. Phase-controlled preparation has been challenging for the metalli... |
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An artificial interphase enables reversible magnesium chemistry in carbonate electrolytes
10.1038/s41557-018-0019-6 2018-04-02 Magnesium-based batteries possess potential advantages over their lithium counterparts. However, reversible Mg chemistry requires a thermodynamically stable electrolyte at low potential, which is usually achieved with corrosive components and at the expense o... |
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A general strategy for synthesis of cyclophane-braced peptide macrocycles via palladium-catalysed intramolecular sp3 C−H arylation
10.1038/s41557-018-0006-y 2018-04-02 New methods capable of effecting cyclization, and forming novel three-dimensional structures while maintaining favourable physicochemical properties are needed to facilitate the development of cyclic peptide-based drugs that can engage challenging biological ... |
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Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules
10.1038/s41557-018-0033-8 2018-04-02 DNA-encoded libraries have emerged as a widely used resource for the discovery of bioactive small molecules, and offer substantial advantages compared with conventional small-molecule libraries. Here, we have developed and streamlined multiple fundamental asp... |
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Single helically folded aromatic oligoamides that mimic the charge surface of double-stranded B-DNA
10.1038/s41557-018-0018-7 2018-04-02 Numerous essential biomolecular processes require the recognition of DNA surface features by proteins. Molecules mimicking these features could potentially act as decoys and interfere with pharmacologically or therapeutically relevant protein–DNA interactions... |
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Single-cell mRNA cytometry via sequence-specific nanoparticle clustering and trapping
10.1038/s41557-018-0025-8 2018-04-02 Cell-to-cell variation in gene expression creates a need for techniques that can characterize expression at the level of individual cells. This is particularly true for rare circulating tumour cells, in which subtyping and drug resistance are of intense inter... |
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Cooperative communication within and between single nanocatalysts
10.1038/s41557-018-0022-y 2018-03-26 Enzymes often show catalytic allostery in which reactions occurring at different sites communicate cooperatively over distances of up to a few nanometres. Whether such effects can occur with non-biological nanocatalysts remains unclear, even though these nano... |
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Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide
10.1038/s41557-018-0023-x 2018-03-26 Mapping free-energy landscapes has proved to be a powerful tool for studying reaction mechanisms. Many complex biomolecular assembly processes, however, have remained challenging to access using this approach, including the aggregation of peptides and protein... |