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Data models to GO-FAIR
10.1038/ng.3910 2017-06-28 This journal and Scientific Data are calling for submissions containing linked open data models that embody and extend the FAIR principles: that data should be findable, accessible, interoperable and reusable by both humans and machines. These principles are ... |
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Promoting transcription over long distances
10.1038/ng.3904 2017-06-28 Promoters and enhancers have long been regarded as distinct elements, a notion that has been challenged more recently. Two new studies now identify promoters that function as long-range enhancers in vivo to regulate the transcription of distal genes. |
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Epigenetic modifier drugs trigger widespread transcription of endogenous retroviruses
10.1038/ng.3902 2017-06-28 A study in this issue demonstrates that epigenome-modifying drugs used in cancer chemotherapy induce transcription from thousands of previously unannotated transcription start sites, most of which are derived from ancient endogenous retroviruses (ERVs). This ... |
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Transposase-driven rearrangements in human tumors
10.1038/ng.3908 2017-06-28 A new study shows that aberrant DNA transposase activity promotes structural alterations that are clonally selected to drive tumor development. This discovery uncovers novel mechanisms of tumor-suppressor gene inactivation and highlights a new approach to can... |
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DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats
10.1038/ng.3889 2017-06-12 Several mechanisms of action have been proposed for DNA methyltransferase and histone deacetylase inhibitors (DNMTi and HDACi), primarily based on candidate-gene approaches. However, less is known about their genome-wide transcriptional and epigenomic consequ... |
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Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
10.1038/ng.3892 2017-06-12 Christopher Amos and colleagues perform genome-wide association analysis for lung cancer using cohorts genotyped on the OncoArray and combing these with existing data. They identify 18 loci, 10 of which are new, finding heterogeneity across the different lung... |
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Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor
10.1038/ng.3896 2017-06-12 Clare Turnbull and colleagues report discovery of 19 new susceptibility loci for testicular germ cell tumor (TGCT) and provide evidence for a network of physical interactions between TGCT risk variants and candidate causal genes. Their findings implicate wide... |
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Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor
10.1038/ng.3879 2017-06-12 Katherine Nathanson, Peter Kanetsky and colleagues present a meta-analysis of five genome-wide association studies of testicular germ cell tumor (TGCT). They identify eight new susceptibility loci and new independent signals at two previously reported loci, p... |
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Between-region genetic divergence reflects the mode and tempo of tumor evolution
10.1038/ng.3891 2017-06-05 Given the implications of tumor dynamics for precision medicine, there is a need to systematically characterize the mode of evolution across diverse solid tumor types. In particular, methods to infer the role of natural selection within established human tumo... |
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Hyperactivation of HUSH complex function by Charcot–Marie–Tooth disease mutation in MORC2
10.1038/ng.3878 2017-06-05 Dominant mutations in the MORC2 gene have recently been shown to cause axonal Charcot–Marie–Tooth (CMT) disease, but the cellular function of MORC2 is poorly understood. Here, through a genome-wide CRISPR–Cas9-mediated forward genetic screen, we identified MO... |