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A current view on inflammation
10.1038/ni.3798 2017-07-19 Evolving mechanistic and conceptual understanding of inflammation drives insight into human disease and new approaches for therapy. |
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A guiding map for inflammation
10.1038/ni.3790 2017-07-19 Netea and colleagues provide a general guide to the cellular and humoral contributors to inflammation as well as the pathways that characterize inflammation in specific organs and tissues. |
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The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation
10.1038/ni.3777 2017-07-19 Autoinflammatory diseases were first recognized nearly 20 years ago as distinct clinical and immunological entities caused by dysregulation in the innate immune system. Since then, advances in genomic techniques have led to the identification of new monogenic... |
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Nutrition, inflammation and cancer
10.1038/ni.3754 2017-07-19 Quantitative and qualitative aspects of nutrition have a profound effect on leukocytes and thereby affect proinflammatory carcinogenic effects or anticancer immune responses. As a result, nutrition affects the incidence, natural progression and therapeutic re... |
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Regulation of inflammation by microbiota interactions with the host
10.1038/ni.3780 2017-07-19 The study of the intestinal microbiota has begun to shift from cataloging individual members of the commensal community to understanding their contributions to the physiology of the host organism in health and disease. Here, we review the effects of the micro... |
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Limiting inflammation—the negative regulation of NF-κB and the NLRP3 inflammasome
10.1038/ni.3772 2017-07-19 A properly mounted immune response is indispensable for recognizing and eliminating danger arising from foreign invaders and tissue trauma. However, the 'inflammatory fire' kindled by the host response must be tightly controlled to prevent it from spreading a... |
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Tumor immunity requires border patrol to fight the enemy within
10.1038/ni.3792 2017-07-19 The infiltration of solid tumors by CD8+ T cells is a favorable prognostic marker. Large-scale transcriptome analysis of tumor-infiltrating T cells from mucosal tumors shows that CD8+ T cells with a CD103+ tissue-resident memory T cell phenotype might be the ... |
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Counting the cost of lineage decisions
10.1038/ni.3794 2017-07-19 Lineage bias among early hematopoietic progenitor cells is specified by transcription-factor programming, and lineage switching reduces the quantity of cells produced. |
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Untangling Fc and complement receptors to kill tumors
10.1038/ni.3797 2017-07-19 Uncoupling of activation of Fc receptors via a mutant IgG1 Fc domain shows a direct role for complement receptors in antibody-dependent tumor killing. |
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α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
10.1038/ni.3796 2017-07-17 How glutamine metabolism orchestrates macrophage activation is unclear. Ho and colleagues show glutamine metabolism tailors the immune responses of macrophages through metabolic and epigenetic reprogramming. |