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Unraveling synthesis of the cryptococcal cell wall and capsule
10.1093/glycob/cwy030 2018-04-10 Fungal pathogens cause devastating infections in millions of individuals each year, representing a huge but underappreciated burden on human health. One of these, the opportunistic fungus Cryptococcus neoformans, kills hundreds of thousands of patients annual... |
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Airway glycomic and allergic inflammatory consequences resulting from keratan sulfate galactose 6-O-sulfotransferase (CHST1) deficiency
10.1093/glycob/cwy025 2018-04-06 Siglec-F is a pro-apoptotic receptor on mouse eosinophils that recognizes 6′-sulfated sialyl Lewis X and 6′-sulfated sialyl N-acetyl-lactosamine as well as multivalent sialyl N-acetyl-lactosamine structures on glycan arrays. We hypothesized that attenuation o... |
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Tn and STn are Members of a Family of Carbohydrate Tumor Antigens that Possess Carbohydrate-Carbohydrate Interactions
10.1093/glycob/cwy032 2018-04-03 The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2,6GalNAcα1Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-bind... |
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Subcellular Distribution of Endogenous Malectin under Rest and Stress Conditions Is Regulated by Ribophorin I
10.1093/glycob/cwy034 2018-04-02 Malectin is a newly discovered endoplasmic reticulum (ER)-resident lectin, which specifically recognizes Glc2Man9GlcNAc2 on newly synthesized glycoproteins. We have previously demonstrated that malectin forms a complex with ribophorin I for selective retentio... |
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Glycoengineering design options for IgG1 in CHO cells using precise gene editing
10.1093/glycob/cwy022 2018-03-27 Precise gene editing technologies are providing new opportunities to stably engineer host cells for recombinant production of therapeutic glycoproteins with different glycan structures. The glycosylation of recombinant therapeutics has long been a focus for b... |
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Demystifying O-GlcNAcylation: hints from peptide substrates
10.1093/glycob/cwy031 2018-03-22 O-GlcNAcylation, analogous to phosphorylation, is an essential post-translational modification of proteins at Ser/Thr residues with a single β-N-acetylglucosamine moiety. This dynamic protein modification regulates many fundamental cellular processes and its ... |
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Global Aspects of Viral Glycosylation Enveloped viruses/herpesvirus/mass spectrometry/mucin type O-glycosylation/viral glycans
10.1093/glycob/cwy021 2018-03-22 Enveloped viruses encompass some of the most common human pathogens causing infections of different severity, ranging from no or very few symptoms to lethal disease as seen with the viral hemorrhagic fevers. All enveloped viruses possess an envelope membrane ... |
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Glycosyltransferase genes that cause monogenic congenital disorders of glycosylation are distinct from glycosyltransferase genes associated with complex diseases
10.1093/glycob/cwy015 2018-03-22 Glycosylation of proteins, lipids and proteoglycans in human cells involves at least 167 identified glycosyltransferases (GTfs), and these orchestrate the biosynthesis of diverse types of glycoconjugates and glycan structures. Mutations in this part of the ge... |
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Crystal structures of an archaeal chitinase ChiD and its ligand complexes
10.1093/glycob/cwy024 2018-03-21 Chitinase D (designated as Pc-ChiD) was found in a hyperthermophilic archaeon, Pyrococcus chitonophagus (previously described as Thermococcus chitonophagus), that was isolated from media containing only chitin as carbon source. Pc-ChiD displays chitinase acti... |
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AANL (Agrocybe aegerita lectin 2) is a new facile tool to probe for O-GlcNAcylation
10.1093/glycob/cwy029 2018-03-19 O-linked N-acetylglucosamine (O-GlcNAcylation) is an important post-translational modification on serine or threonine of proteins, mainly observed in nucleus or cytoplasm. O-GlcNAcylation regulates many cell processes, including transcription, cell cycle, neu... |