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Double-barreled gun: Combination of PARP inhibitor with conventional chemotherapy
10.1016/j.pharmthera.2018.03.006 2018-04-03 DNA repair pathways are evolutionarily conserved molecular mechanisms that maintain the integrity of genomic DNA. In cancer therapies, the integrity and activity of DNA repair pathways predict therapy resistance and disease outcome. Members of the poly (ADP-r... |
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Extracellular vesicles as potential biomarkers for alcohol- and drug-induced liver injury and their therapeutic applications
10.1016/j.pharmthera.2018.03.009 2018-04-03 Extracellular vesicles (EVs) are small membranous vesicles originating from various cells and tissues, including the liver parenchymal hepatocytes and nonparenchymal cells such as Kupffer and stellate cells. Recently, the pathophysiological role of EVs, such ... |
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ROCK inhibition in models of neurodegeneration and its potential for clinical translation
10.1016/j.pharmthera.2018.03.008 2018-04-03 Neurodegenerative disorders like Parkinson’s disease, Alzheimer’s disease, or amyotrophic lateral sclerosis are affecting a rapidly increasing population worldwide. While common pathomechanisms such as protein aggregation, axonal degeneration, dysfunction of ... |
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Arthropod toxins and their antinociceptive properties: From venoms to painkillers
10.1016/j.pharmthera.2018.03.007 2018-03-29 The complex process of pain control commonly involves the use of systemic analgesics; however, in many cases, a more potent and effective polypharmacological approach is needed to promote clinically significant improvement. Additionally, considering side effe... |
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Targeting the replication stress response in cancer
10.1016/j.pharmthera.2018.03.005 2018-03-24 Many conventional chemotherapies used in cancer treatment exert their effect by inflicting DNA damage. Highly proliferative tissues, as well as tumour cells, are particularly vulnerable to this damage resulting in unwanted toxicities. In contrast, a targeted ... |
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Sirtuin activators and inhibitors: Promises, achievements, and challenges
10.1016/j.pharmthera.2018.03.004 2018-03-22 The NAD+-dependent protein lysine deacylases of the Sirtuin family regulate various physiological functions, from energy metabolism to stress responses. The human Sirtuin isoforms, SIRT1–7, are considered attractive therapeutic targets for aging-related disea... |
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Racing the clock: The role of circadian rhythmicity in addiction across the lifespan ☆
10.1016/j.pharmthera.2018.03.003 2018-03-15 Although potent effects of psychoactive drugs on circadian rhythms were first described over 30 years ago, research into the reciprocal relationship between the reward system and the circadian system – and the impact of this relationship on addiction – has on... |
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Canine sarcomas as a surrogate for the human disease
10.1016/j.pharmthera.2018.01.012 2018-03-09 Pet dogs are becoming increasingly recognized as a population with the potential to inform medical research through their treatment for a variety of maladies by veterinary health professionals. This is the basis of the One Health initiative, supporting the id... |
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Discovery of Leonuri and therapeutical applications: From bench to bedside
10.1016/j.pharmthera.2018.01.006 2018-03-09 Despite several advances in percutaneous coronary intervention and the discovery of new drugs, the incidence of myocardial infarction and deaths due to cardiovascular diseases (CVD) has not decreased markedly in China. The quality of life is affected seriousl... |
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The Role of TAM Family Receptors and Ligands in the Nervous System: From Development to Pathobiology ☆
10.1016/j.pharmthera.2018.03.002 2018-03-04 Tyro3, Axl, and Mertk, referred to as the TAM family of receptor tyrosine kinases, are instrumental in maintaining cell survival and homeostasis in mammals. TAM receptors interact with multiple signaling molecules to regulate cell migration, survival, phagocy... |