Nanomedicine: Nanotechnology, Biology and Medicine


High sensitive and multiple detection of Acute Myocardial Infarction Biomarkers based on a dual-readout Immunochromatography Test Strip ☆ ☆☆ 10.1016/j.nano.2018.02.013 2018-03-28 Immunochromatography test strip (ICTS) displayed high advantages in screening acute myocardial infarction (AMI) biomarkers. However, the low sensitivity and nonquantitative results seriously limited its clinical application. Herein, we designed a high sensiti...
Screening for canine transitional cell carcinoma (TCC) by SERS-based quantitative urine cytology ☆ ☆☆ ☆☆☆ 10.1016/j.nano.2018.03.001 2018-03-27 Canine lower urinary tract neoplasia is a clinically important disease process that has high mortality due to late stage diagnosis and poorly durable response to treatment. Non-invasive diagnostic techniques (e.g. dipstick test, urine cytology) currently have...
Nanomagnetic Modulation of Tumor Redox State ☆ 10.1016/j.nano.2018.03.002 2018-03-26 Modulation of reactive oxygen and nitrogen species in a tumor could be exploited for nanotherapeutic benefits. We investigate the antitumor effect in Walker-256 carcinosarcoma of magnetic nanodots composed of doxorubicin-loaded Fe3O4 nanoparticles combined wi...
Polymersome nanoparticles for delivery of Wnt-activating small molecules ☆ ☆☆ 10.1016/j.nano.2018.02.014 2018-03-17 Spatiotemporal control of drug delivery is important for a number of medical applications which may be achieved using polymersome nanoparticles (PMs). Wnt signalling is a molecular pathway activated in various physiological processes, including bone repair, t...
In Vitro Studies of Heparin-Coated Magnetic Nanoparticles for Use in the Treatment of Neointimal Hyperplasia ☆ 10.1016/j.nano.2018.02.011 2018-03-08 Restenosis by neointimal hyperplasia is still an ongoing concern in endovascular surgery. Slowing vascular smooth muscle cell (VSMC) proliferation by reversing the phenotype change, would allow vessel healing and re-endotheliazation. To accomplish this, we ha...
In vivo efficacy and pharmacokinetics of bi-aryl oxazolidinone RBx 11,760 loaded polylactic acid–polyethylene glycol nanoparticles in mouse hematogenous bronchopneumonia and rat groin abscess caused by Staphylococcus aureus ☆ 10.1016/j.nano.2018.02.003 2018-03-07 RBx 11,760 is a bi-aryl oxazolidinone antibacterial agent active against Staphylococcus aureus but has poor solubility. Here we have encapsulated RBx 11,760 in PLA–PEG NPs with an aim to improve physicochemical, pharmacokinetics and in vivo efficacy. The aver...
A nano silicon adjuvant enhances inactivated transmissible gastroenteritis vaccine through activation the Toll-like receptors and promotes humoral and cellular immune responses ☆ ☆☆ 10.1016/j.nano.2018.02.010 2018-03-01 Inactivated transmissible gastroenteritis virus (TGEV) vaccines are widely used in swine herds in China. These are limited, however, by the need to elicit both humoral and cellular immunity, as well as the efficiency of adjuvants. In this study, a 70-nm nano ...
A visible fluorescent nanovaccine based on functional genipin crosslinked ovalbumin protein nanoparticles ☆ 10.1016/j.nano.2018.02.007 2018-02-21 Accurate and efficient antigen delivery is crucial for inducing a strong and long-term immune response. A visible protein nanovaccine made from antigen could provide a novel and promising technology for secure and efficient delivery of the antigen with imagin...
Neuroprotective Effect of Gold Nanoparticles Composites in Parkinson's Disease Model ☆ ☆☆ 10.1016/j.nano.2018.01.020 2018-02-21 Parkinson’s disease (PD) is second most common neurodegenerative disorder worldwide. Although drugs and surgery can relieve the symptoms of PD, these therapies are incapable of fundamentally treating the disease. For PD patients, over-expression of α-synuclei...
Enhancing Glioblastoma Treatment using Cisplatin-Gold-Nanoparticle Conjugates and Targeted Delivery with Magnetic Resonance-Guided Focused Ultrasound ☆ ☆☆ 10.1016/j.nano.2018.01.021 2018-02-20 Glioblastoma (GBM) is the most common and aggressive primary brain tumor resulting in high rates of morbidity and mortality. A strategy to increase the efficacy of available drugs and enhance the delivery of chemotherapeutics through the blood brain barrier (...

High sensitive and multiple detection of Acute Myocardial Infarction Biomarkers based on a dual-readout Immunochromatography Test Strip ☆ ☆☆

10.1016/j.nano.2018.02.013

2018-03-28

Immunochromatography test strip (ICTS) displayed high advantages in screening acute myocardial infarction (AMI) biomarkers. However, the low sensitivity and nonquantitative results seriously limited its clinical application. Herein, we designed a high sensiti...

Screening for canine transitional cell carcinoma (TCC) by SERS-based quantitative urine cytology ☆ ☆☆ ☆☆☆

10.1016/j.nano.2018.03.001

2018-03-27

Canine lower urinary tract neoplasia is a clinically important disease process that has high mortality due to late stage diagnosis and poorly durable response to treatment. Non-invasive diagnostic techniques (e.g. dipstick test, urine cytology) currently have...

Nanomagnetic Modulation of Tumor Redox State ☆

10.1016/j.nano.2018.03.002

2018-03-26

Modulation of reactive oxygen and nitrogen species in a tumor could be exploited for nanotherapeutic benefits. We investigate the antitumor effect in Walker-256 carcinosarcoma of magnetic nanodots composed of doxorubicin-loaded Fe3O4 nanoparticles combined wi...

Polymersome nanoparticles for delivery of Wnt-activating small molecules ☆ ☆☆

10.1016/j.nano.2018.02.014

2018-03-17

Spatiotemporal control of drug delivery is important for a number of medical applications which may be achieved using polymersome nanoparticles (PMs). Wnt signalling is a molecular pathway activated in various physiological processes, including bone repair, t...

In Vitro Studies of Heparin-Coated Magnetic Nanoparticles for Use in the Treatment of Neointimal Hyperplasia ☆

10.1016/j.nano.2018.02.011

2018-03-08

Restenosis by neointimal hyperplasia is still an ongoing concern in endovascular surgery. Slowing vascular smooth muscle cell (VSMC) proliferation by reversing the phenotype change, would allow vessel healing and re-endotheliazation. To accomplish this, we ha...

In vivo efficacy and pharmacokinetics of bi-aryl oxazolidinone RBx 11,760 loaded polylactic acid–polyethylene glycol nanoparticles in mouse hematogenous bronchopneumonia and rat groin abscess caused by Staphylococcus aureus ☆

10.1016/j.nano.2018.02.003

2018-03-07

RBx 11,760 is a bi-aryl oxazolidinone antibacterial agent active against Staphylococcus aureus but has poor solubility. Here we have encapsulated RBx 11,760 in PLA–PEG NPs with an aim to improve physicochemical, pharmacokinetics and in vivo efficacy. The aver...

A nano silicon adjuvant enhances inactivated transmissible gastroenteritis vaccine through activation the Toll-like receptors and promotes humoral and cellular immune responses ☆ ☆☆

10.1016/j.nano.2018.02.010

2018-03-01

Inactivated transmissible gastroenteritis virus (TGEV) vaccines are widely used in swine herds in China. These are limited, however, by the need to elicit both humoral and cellular immunity, as well as the efficiency of adjuvants. In this study, a 70-nm nano ...

A visible fluorescent nanovaccine based on functional genipin crosslinked ovalbumin protein nanoparticles ☆

10.1016/j.nano.2018.02.007

2018-02-21

Accurate and efficient antigen delivery is crucial for inducing a strong and long-term immune response. A visible protein nanovaccine made from antigen could provide a novel and promising technology for secure and efficient delivery of the antigen with imagin...

Neuroprotective Effect of Gold Nanoparticles Composites in Parkinson's Disease Model ☆ ☆☆

10.1016/j.nano.2018.01.020

2018-02-21

Parkinson’s disease (PD) is second most common neurodegenerative disorder worldwide. Although drugs and surgery can relieve the symptoms of PD, these therapies are incapable of fundamentally treating the disease. For PD patients, over-expression of α-synuclei...

Enhancing Glioblastoma Treatment using Cisplatin-Gold-Nanoparticle Conjugates and Targeted Delivery with Magnetic Resonance-Guided Focused Ultrasound ☆ ☆☆

10.1016/j.nano.2018.01.021

2018-02-20

Glioblastoma (GBM) is the most common and aggressive primary brain tumor resulting in high rates of morbidity and mortality. A strategy to increase the efficacy of available drugs and enhance the delivery of chemotherapeutics through the blood brain barrier (...