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Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia
10.1038/s41467-018-03178-z 2018-04-09 Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis ... |
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Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
10.1038/s41467-018-03753-4 2018-04-09 Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by tracking individual tubular cells in conditional Pax8/Confetti mice that k... |
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Designable ultra-smooth ultra-thin solid-electrolyte interphases of three alkali metal anodes
10.1038/s41467-018-03466-8 2018-04-09 Dendrite growth of alkali metal anodes limited their lifetime for charge/discharge cycling. Here, we report near-perfect anodes of lithium, sodium, and potassium metals achieved by electrochemical polishing, which removes microscopic defects and creates ultra... |
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Stimulus dependent diversity and stereotypy in the output of an olfactory functional unit
10.1038/s41467-018-03837-1 2018-04-09 Olfactory inputs are organized in an array of functional units (glomeruli), each relaying information from sensory neurons expressing a given odorant receptor to a small population of output neurons, mitral/tufted (MT) cells. MT cells respond heterogeneously ... |
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Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling
10.1038/s41467-018-03801-z 2018-04-09 Branching morphogenesis is a general mechanism that increases the surface area of an organ. In chicken feathers, the flat epithelial sheath at the base of the follicle is transformed into periodic branches. How exactly the keratinocytes are organized into thi... |
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Systematic design and experimental demonstration of bianisotropic metasurfaces for scattering-free manipulation of acoustic wavefronts
10.1038/s41467-018-03778-9 2018-04-09 Recent advances in gradient metasurfaces have shown that by locally controlling the bianisotropic response of the cells one can ensure full control of refraction, that is, arbitrarily redirect the waves without scattering into unwanted directions. In this wor... |
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Archean phosphorus liberation induced by iron redox geochemistry
10.1038/s41467-018-03835-3 2018-04-09 The element phosphorus (P) is central to ecosystem growth and is proposed to be a limiting nutrient for life. The Archean ocean may have been strongly phosphorus-limited due to the selective binding of phosphate to iron oxyhydroxide. Here we report a new rout... |
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Recurrent acquisition of cytosine methyltransferases into eukaryotic retrotransposons
10.1038/s41467-018-03724-9 2018-04-09 Transposable elements are in a constant arms race with the silencing mechanisms of their host genomes. One silencing mechanism commonly used by many eukaryotes is dependent on cytosine methylation, a covalent modification of DNA deposited by C5 cytosine methy... |
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Drought drives rapid shifts in tropical rainforest soil biogeochemistry and greenhouse gas emissions
10.1038/s41467-018-03352-3 2018-04-09 Climate change models predict more frequent and severe droughts in the humid tropics. How drought will impact tropical forest carbon and greenhouse gas dynamics is poorly understood. Here we report the effects of the severe 2015 Caribbean drought on soil mois... |
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Quantitative 3D determination of self-assembled structures on nanoparticles using small angle neutron scattering
10.1038/s41467-018-03699-7 2018-04-09 The ligand shell (LS) determines a number of nanoparticles’ properties. Nanoparticles’ cores can be accurately characterized; yet the structure of the LS, when composed of mixture of molecules, can be described only qualitatively (e.g., patchy, Janus, and ran... |