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Real-time 3D single-molecule localization using experimental point spread functions
10.1038/nmeth.4661 2018-04-09 We present a real-time fitter for 3D single-molecule localization microscopy using experimental point spread functions (PSFs) that achieves minimal uncertainty in 3D on any microscope and is compatible with any PSF engineering approach. We used this method to... |
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FateID infers cell fate bias in multipotent progenitors from single-cell RNA-seq data
10.1038/nmeth.4662 2018-04-09 To understand stem cell differentiation along multiple lineages, it is necessary to resolve heterogeneous cellular states and the ancestral relationships between them. We developed a robotic miniaturized CEL-Seq2 implementation to carry out deep single-cell R... |
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How to pull the blanket off dormant cancer cells
10.1038/nmeth.4640 2018-04-03 How to pull the blanket off dormant cancer cells How to pull the blanket off dormant cancer cells, Published online: 03 April 2018; doi:10.1038/nmeth.4640When asleep, cancer cells can evade chemo. When they wake up, they can cause cancer recurrence. By deciph... |
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Points of Significance: Statistics versus machine learning
10.1038/nmeth.4642 2018-04-03 Points of Significance: Statistics versus machine learning Points of Significance: Statistics versus machine learning, Published online: 03 April 2018; doi:10.1038/nmeth.4642Statistics draws population inferences from a sample, and machine learning finds gene... |
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Genomics: Single-cell hat trick
10.1038/nmeth.4646 2018-04-03 Genomics: Single-cell hat trick Genomics: Single-cell hat trick, Published online: 03 April 2018; doi:10.1038/nmeth.4646Genomics: Single-cell hat trick |
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Genomics: Off-targets in epigenome editing
10.1038/nmeth.4650 2018-04-03 Genomics: Off-targets in epigenome editing Genomics: Off-targets in epigenome editing, Published online: 03 April 2018; doi:10.1038/nmeth.4650Genomics: Off-targets in epigenome editing |
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Stem cells: From somatic cells to naive pluripotent cells
10.1038/nmeth.4648 2018-04-03 Stem cells: From somatic cells to naive pluripotent cells Stem cells: From somatic cells to naive pluripotent cells, Published online: 03 April 2018; doi:10.1038/nmeth.4648Stem cells: From somatic cells to naive pluripotent cells |
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Genomics: Genome editing with ease
10.1038/nmeth.4652 2018-04-03 Genomics: Genome editing with ease Genomics: Genome editing with ease, Published online: 03 April 2018; doi:10.1038/nmeth.4652Genomics: Genome editing with ease |
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Neuroscience: Minimally invasive optogenetics
10.1038/nmeth.4654 2018-04-03 Neuroscience: Minimally invasive optogenetics Neuroscience: Minimally invasive optogenetics, Published online: 03 April 2018; doi:10.1038/nmeth.4654Upconversion nanoparticles can serve as intermediaries to illuminate optogenetic tools in the mouse brain. |
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Cell biology: Live-streaming the cytoplasm
10.1038/nmeth.4656 2018-04-03 Cell biology: Live-streaming the cytoplasm Cell biology: Live-streaming the cytoplasm, Published online: 03 April 2018; doi:10.1038/nmeth.4656A new approach uses beams of light to direct cytoplasmic flows. |