重酒石酸二氢可待因酮
重酒石酸二氢可待因酮结构式
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常用名 | 重酒石酸二氢可待因酮 | 英文名 | hydrocodone bitartrate |
|---|---|---|---|---|
| CAS号 | 143-71-5 | 分子量 | 449.45100 | |
| 密度 | N/A | 沸点 | 461.4ºC at 760 mmHg | |
| 分子式 | C22H27NO9 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 232.9ºC |
| 中文名 | 重酒石酸二氢可待因酮 |
|---|---|
| 英文名 | (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one,(2R,3R)-2,3-dihydroxybutanedioic acid |
| 英文别名 | 更多 |
| 沸点 | 461.4ºC at 760 mmHg |
|---|---|
| 分子式 | C22H27NO9 |
| 分子量 | 449.45100 |
| 闪点 | 232.9ºC |
| 精确质量 | 449.16900 |
| PSA | 153.83000 |
| 蒸汽压 | 1.07E-08mmHg at 25°C |
| 储存条件 | 2-8°C |
| 水溶解性 | H2O: 62 mg/mL |
| 计算化学 | 1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:4 3.氢键受体数量:10 4.可旋转化学键数量:4 5.互变异构体数量:3 6.拓扑分子极性表面积154 7.重原子数量:32 8.表面电荷:0 9.复杂度:642 10.同位素原子数量:0 11.确定原子立构中心数量:6 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:2 |
| 更多 | 1.溶解性：H2O: 62mg/mL。 |
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| 危害码 (欧洲) | F,T |
| 风险声明 (欧洲) | 23/25-36/38 |
| 安全声明 (欧洲) | S7;S16;S24;S33;S45 |
| 危险品运输编码 | UN 1230 3/PG 2 |
| WGK德国 | 3 |
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~56%
重酒石酸二氢可待因酮 143-71-5 |
| 文献：ZENTIVA, A.S. Patent: WO2005/100361 A1, 2005 ; Location in patent: Page/Page column 5-6 ; |
| 重酒石酸二氢可待因酮上游产品 2 | |
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| 重酒石酸二氢可待因酮下游产品 1 | |
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Effect of cytochrome P450 2D1 inhibition on hydrocodone metabolism and its behavioral consequences in rats.
J. Pharmacol. Exp. Ther. 280 , 1374-1382, (1997) Humans that lack cytochrome P450 2D6 (CYP2D6) activity may have an altered risk of drug dependence or abuse because this enzyme is important in the metabolism of some drugs of abuse, including hydroco... |
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Mu receptor binding of some commonly used opioids and their metabolites.
Life Sci. 48 , 2165-2171, (1991) The binding affinity to the mu receptor of some opioids chemically related to morphine and some of their metabolites was examined in rat brain homogenates with 3H-DAMGO. The chemical group at position... |
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The antitussive activity of delta-opioid receptor stimulation in guinea pigs.
J. Pharmacol. Exp. Ther. 292 , 803-809, (2000) In this study, the activity of the delta-opioid receptor subtype-selective agonist, SB 227122, was investigated in a guinea pig model of citric acid-induced cough. Parenteral administration of selecti... |
| Robidone |
| EINECS 205-608-1 |
| Synkonin |
| MFCD00078557 |
| Codone |
| Dicotrate |
| Dicodrine |
| Dicodethal |
| Stodcodon |
| Biocodone |
| 4,5-epoxy-3-methoxy-17-methylmorphinan-6-one bitartrate |
| Hycon |
| hydrocodone ditartrate |
| Hydrokon |
