3-Methyl-2-butenoic acid [8-hydroxymethyl-1,5-dimethyl-5-(4-methyl-3-pentenyl)-12-oxabicyclo[9.1.0]dodeca-3,7-dien-2-yl] ester

更新时间：2024-01-19 22:03:48

3-Methyl-2-butenoic acid [8-hydroxymethyl-1,5-dimethyl-5-(4-methyl-3-pentenyl)-12-oxabicyclo[9.1.0]dodeca-3,7-dien-2-yl] ester结构式	常用名	3-Methyl-2-butenoic acid [8-hydroxymethyl-1,5-dimethyl-5-(4-methyl-3-pentenyl)-12-oxabicyclo[9.1.0]dodeca-3,7-dien-2-yl] ester	英文名	3-Methyl-2-butenoic acid [8-hydroxymethyl-1,5-dimethyl-5-(4-methyl-3-pentenyl)-12-oxabicyclo[9.1.0]dodeca-3,7-dien-2-yl] ester
	CAS号	72506-14-0	分子量	402.57
	密度	1.1±0.1 g/cm3	沸点	501.0±50.0 °C at 760 mmHg
	分子式	C₂₅H₃₈O₄	熔点	N/A
	MSDS	N/A	闪点	158.5±23.6 °C

用途

Vibsanin A是一种蛋白激酶C(PKC)激活剂,对人类癌细胞系具有抗增殖活性。Vibsanin A也是一种HSP90抑制剂[1]。

英文名	(1R,2R,5S,7E,11R)-8-(Hydroxymethyl)-1,5-dimethyl-5-(4-methyl-3-penten-1-yl)-12-oxabicyclo[9.1.0]dodeca-3,7-dien-2-yl 3-methyl-2-butenoate
英文别名	更多

描述	Vibsanin A是一种蛋白激酶C(PKC)激活剂,对人类癌细胞系具有抗增殖活性。Vibsanin A也是一种HSP90抑制剂[1]。
相关类别	信号通路 >> 表观遗传学 >> PKC 研究领域 >> 癌症信号通路 >> 代谢酶/蛋白酶 >> HSP 信号通路 >> 细胞周期/DNA损伤 >> HSP 信号通路 >> TGF-beta/Smad 信号通路 >> PKC
参考文献	[1]. Miura K, et, al. Identification of vibsanin A analog as a novel HSP90 inhibitor. Bioorg Med Chem. 2020 Jan 15;28(2):115253. [2]. Shen X, et, al. Vibsanin A sensitizes human acute myeloid leukemia cells to tyrosine kinase inhibitor-induced myeloid differentiation via activation of PKC and upregulation of Lyn. Biochem Biophys Res Commun. 2018 Jul 7;502(1):110-115.

描述

Vibsanin A是一种蛋白激酶C(PKC)激活剂,对人类癌细胞系具有抗增殖活性。Vibsanin A也是一种HSP90抑制剂[1]。

相关类别

信号通路 >> 表观遗传学 >> PKC

研究领域 >> 癌症

信号通路 >> 代谢酶/蛋白酶 >> HSP

信号通路 >> 细胞周期/DNA损伤 >> HSP

信号通路 >> TGF-beta/Smad 信号通路 >> PKC

参考文献

[1]. Miura K, et, al. Identification of vibsanin A analog as a novel HSP90 inhibitor. Bioorg Med Chem. 2020 Jan 15;28(2):115253.

[2]. Shen X, et, al. Vibsanin A sensitizes human acute myeloid leukemia cells to tyrosine kinase inhibitor-induced myeloid differentiation via activation of PKC and upregulation of Lyn. Biochem Biophys Res Commun. 2018 Jul 7;502(1):110-115.

密度	1.1±0.1 g/cm3
沸点	501.0±50.0 °C at 760 mmHg
分子式	C₂₅H₃₈O₄
分子量	402.57
闪点	158.5±23.6 °C
精确质量	402.277008
LogP	7.24
蒸汽压	0.0±2.9 mmHg at 25°C
折射率	1.528

2-Butenoic acid, 3-methyl-, (1R,2R,5S,7E,11R)-8-(hydroxymethyl)-1,5-dimethyl-5-(4-methyl-3-penten-1-yl)-12-oxabicyclo[9.1.0]dodeca-3,7-dien-2-yl ester

2-Butenoic acid, 3-methyl-, (1R,2R,3E,5S,7E,11R)-8-(hydroxymethyl)-1,5-dimethyl-5-(4-methyl-3-penten-1-yl)-12-oxabicyclo[9.1.0]dodeca-3,7-dien-2-yl ester

(1R,2R,5S,7E,11R)-8-(Hydroxymethyl)-1,5-dimethyl-5-(4-methyl-3-penten-1-yl)-12-oxabicyclo[9.1.0]dodeca-3,7-dien-2-yl 3-methyl-2-butenoate

3-Methyl-2-butenoic acid [8-hydroxymethyl-1,5-dimethyl-5-(4-methyl-3-pentenyl)-12-oxabicyclo[9.1.0]dodeca-3,7-dien-2-yl] ester

用途

名称

生物活性

物理化学性质

英文别名