4,4'-二氨基二苯醚(ODA)

4,4'-二氨基二苯醚(ODA)用途

用于制耐热性塑料如聚酰亚胺树脂、聚马来酰亚胺树脂、聚酰胺酰亚胺树脂、聚酯酰亚胺树脂、环氧树脂、聚氨酯等，也用作交联剂。本品用作环氧树脂的固化剂，固化物热变形温度高，热稳定好，耐化学药品性能及耐水性能优良。
本品是耐热型塑料聚酰胺酰亚胺树脂、聚酯酰亚胺树脂、聚酰亚胺树脂、聚马来酰亚胺树脂等的原料。用作环氧树脂的固化剂，固化物热变形温度高，热稳定好，耐化学药品性能及耐水性能优良。也是耐热型塑料聚酰胺酰亚胺树脂、聚酯酰亚胺树脂、聚酰亚胺树脂、聚马来酰亚胺树脂等的原料。

4,4'-二氨基二苯醚(ODA)名称

[ CAS 号 ]:
101-80-4

[ 中文名 ]:
4,4'-二氨基二苯醚

[ 英文名 ]:
4,4'-Oxydianiline

[中文别名 ]:

4,4’-二氨基二苯醚

[英文别名 ]:

Bis(p-aminophenyl) ether
p,p'-Diaminodiphenyl ether
4,4’-Oxydianiline
EINECS 202-977-0
Oxydianiline
4,4'-Diaminodiphenyl ether
4,4-Oxydianiline
4,4'-Oxydianiline
ZR DOR DZ
Benzenamine, 4,4'-oxybis-

4,4'-二氨基二苯醚(ODA)物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
389.4±27.0 °C at 760 mmHg

[ 熔点 ]:
188-192 °C(lit.)

[ 分子式 ]:
C₁₂H₁₂N₂O

[ 分子量 ]:
200.236

[ 闪点 ]:
218.9±0.0 °C

[ 精确质量 ]:
200.094955

[ PSA ]:
61.27000

[ LogP ]:
0.51

[ 外观性状 ]:
无气味的无色晶体或一种无气味的细,米色粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.666

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents. Hygroscopic.

[ 水溶解性 ]:
Insoluble.

4,4'-二氨基二苯醚(ODA)MSDS

详细MSDS(安全技术说明书)

4,4'-二氨基二苯醚(ODA)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BY7900000

CHEMICAL NAME :: Aniline, 4,4'-oxydi-

CAS REGISTRY NUMBER :: 101-80-4

BEILSTEIN REFERENCE NO. :: 0475735

LAST UPDATED :: 199710

DATA ITEMS CITED :: 43

MOLECULAR FORMULA :: C12-H12-N2-O

MOLECULAR WEIGHT :: 200.26

WISWESSER LINE NOTATION :: ZR DOR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 725 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 365 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 685 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4277 mg/kg/13W-C

TOXIC EFFECTS :: Endocrine - thyroid weight (goiter) Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 619 mg/kg/26W-I

TOXIC EFFECTS :: Cardiac - EKG changes not diagnostic of specified effects Vascular - BP elevation not characterized in autonomic section

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1087 mg/kg/15D-I

TOXIC EFFECTS :: Endocrine - changes in adrenal weight Endocrine - changes in spleen weight Blood - pigmented or nucleated red blood cells

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2366 mg/kg/13W-C

TOXIC EFFECTS :: Endocrine - thyroid weight (goiter) Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8652 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Endocrine - thyroid tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8550 mg/kg/76W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Eye) - tumors Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7000 mg/kg/39W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - leukemia

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 19 gm/kg/77W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Blood - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11 gm/kg/30W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - leukemia

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8652 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Endocrine - thyroid tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 69216 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Endocrine - thyroid tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12978 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Sense Organs and Special Senses (Eye) - tumors

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 50 mg/L

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 236,933,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,203,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,203,1982 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Carcinogen JAN 1993 OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0239 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 45 (estimated)

4,4'-二氨基二苯醚(ODA)安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H317-H340-H350-H361-H410

[ 警示性声明 ]:
P201-P261-P273-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R45;R46;R62;R23/24/25;R51/53

[ 安全声明 (欧洲) ]:
S53-S45-S61-S36/37-S26-S20

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
BY7900000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29222900

4,4'-二氨基二苯醚(ODA)合成路线

详细合成路线

4,4'-二氨基二苯醚(ODA)上下游产品

4,4'-二氨基二苯醚(ODA)上游产品

4,4'-二氨基二苯醚(ODA)下游产品

4,4'-二氨基二苯醚(ODA)制备

(1)缩合反应将溶剂硝基苯515kg加入搅拌反应釜中，然后搅拌下将145kg硝基氯苯、123.5kg对硝基苯酚、95.7kg碳酸钠和6.18kg氯化钾依次加入搅拌反应釜中，搅拌下升温至210～215℃后，保持此温度下搅拌反应24h。缩合反应完成后，冷却，将缩合物抽至蒸馏装置，先进行真空蒸馏，当硝基苯蒸出350～400L时，改为水蒸气蒸馏，蒸至馏出液中无硝基苯时为止。剩余物经吸滤，滤液再用水洗涤至不带色，即制得4,4’-二硝基二苯醚。

(2)还原反应将丁醇918kg加入还原反应釜内，搅拌下加入10kg氯化铵，50kg铁屑，升温至95℃时加入4,4’-二硝基二苯醚25kg，搅拌反应0.5h。再加入第二批铁屑40kg，4,4’-二硝基二苯醚20kg，搅拌反应0.5h。然后加入第三批铁屑40kg，4,4’-二硝基二苯醚20kg，仍维持反应温度100℃，反应1.5h取样分析反应终点。反应结束后，加入亚硫酸氢钠12kg，搅拌溶解后，将反应物料趁热用管式吸滤器抽至结晶釜内冷却结晶约8h。然后经过过滤，滤液丁醇经蒸馏后循环使用，滤饼水洗至无丁醇为止，即得粗品4,4’-二氨基二苯醚。

(3)产品精制将340kg水、60kg30%的盐酸加入溶解槽，搅拌下加入粗品4,4’-二氨基二苯醚和1.5kg柠檬酸、1kg亚硫酸氢钠，加热升温至60℃，再加入活性炭9kg。继续升温至80℃，保持0.5h。冷却后过滤，将滤液加入中和槽，搅拌下加入亚硫酸氢钠0.5kg，再慢慢加入氨水，保持温度在30℃以下，中和至物料的pH值为8～9，则4,4’-二氨基二苯醚晶体从溶液中析出。经过滤，滤饼用水洗至中性及无氯离子存在，抽滤后进行真空干燥。

将干燥后的4,4’-二氨基二苯醚加入升华器中，抽真空至26.66Pa以下，加热升温至185～190℃，4,4’-二氨基二苯醚气化，进入结晶室，在结晶室内被冷却而结晶，结晶室温度控制在135～145℃。当结晶室温度显著下降时即升华结束，冷却升华器，使结晶室温度降至50℃时进行出料，即得成品。升华操作每批约需10h。

4,4'-二氨基二苯醚(ODA)海关

[ 海关编码 ]: 2922299090

[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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