7-Oxotridecanedioic acid

7-Oxotridecanedioic acid用途

7-Oxotridecanedioic acid 是一种可降解的阳离子脂质中间体 (lipid intermediate ) 化合物,用于脂质纳米颗粒的形成。7-Oxotridecanedioic acid 可被嵌到脂质颗粒中以提供活性物质。

7-Oxotridecanedioic acid名称

[ CAS 号 ]:
101171-43-1

[ 英文名 ]:
7-Oxotridecanedioic acid

[英文别名 ]:

7-oxo-trideca-2(Z),11(Z)-diene dinitrile
7-oxo-trideca-2,11-dienedinitrile
7-oxo-tridecane-1,13-dioic acid
7-oxo-tridecanedioic acid
(2Z,11Z)-7-oxotrideca-2,11-dienedinitrile
7-Oxo-tridecandisaeure
(Z,Z)-tridecan-2,11-diene-7-one-1,13-dinitrile
2,11-Tridecadienedinitrile,7-oxo-,(2Z,11Z)

7-Oxotridecanedioic acid生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

这些阳离子脂质可并入脂质粒子中以传递活性剂,例如核酸。7-氧三叉二甲酸从专利US20150005363中提取,中间体12[1]。

[参考文献]

[1]. Martin A Maier, et al. Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics. Mol Ther. 2013 Aug;21(8):1570-8.

[2]. Steven M Ansell, et al. Branched Alkyl And Cycloalkyl Terminated Biodegradable Lipids For The Delivery Of Active Agents. Patent US20150005363A1

7-Oxotridecanedioic acid物理化学性质

[ 密度 ]:
1.125g/cm3

[ 沸点 ]:
490.2ºC at 760 mmHg

[ 分子式 ]:
C₁₃H₂₂O₅

[ 分子量 ]:
258.31100

[ 闪点 ]:
264.4ºC

[ 精确质量 ]:
258.14700

[ PSA ]:
91.67000

[ LogP ]:
2.62570

[ 蒸汽压 ]:
5.96E-11mmHg at 25°C

[ 折射率 ]:
1.482

7-Oxotridecanedioic acid安全信息

[ 海关编码 ]:
2918300090

7-Oxotridecanedioic acid海关

[ 海关编码 ]: 2918300090

[ 中文概述 ]:
2918300090 其他含醛基或酮基不含其他含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%