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石杉碱甲B

石杉碱甲B用途

Huperzine B 是从 Huperzia serrata 中分离出的石蒜生物碱和高度选择性的乙酰胆碱酯酶 (AChE) 抑制剂。Huperzine B 可以用于改善阿尔茨海默氏病。

石杉碱甲B名称

[ CAS 号 ]:
103548-82-9

[ 中文名 ]:
石杉碱乙

[ 英文名 ]:
Huperzine B

[中文别名 ]:

[英文别名 ]:

HuperzineB

石杉碱甲B生物活性

[ 描述 ]:

Huperzine B 是从 Huperzia serrata 中分离出的石蒜生物碱和高度选择性的乙酰胆碱酯酶 (AChE) 抑制剂。Huperzine B 可以用于改善阿尔茨海默氏病。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> 疼痛

[ 靶点 ]

AChE[1]

[参考文献]

[1]. Zhang HY, et al. Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells. Neurosci Lett. 2000 Sep 29;292(1):41-4.

[2]. He XC, et al. Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B. Bioorg Med Chem. 2007 Feb 1;15(3):1394-408.

石杉碱甲B物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
533.5±50.0 °C at 760 mmHg

[ 分子式 ]:
C₁₆H₂₀N₂O

[ 分子量 ]:
256.343

[ 闪点 ]:
216.4±30.3 °C

[ 精确质量 ]:
256.157562

[ PSA ]:
44.89000

[ LogP ]:
1.98

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.624

[ 储存条件 ]:
室温

石杉碱甲B毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OL2780000

CHEMICAL NAME :: Lycodin-1(18H)-one, 8,15-didehydro-

CAS REGISTRY NUMBER :: 103548-82-9

LAST UPDATED :: 198912

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C16-H20-N2-O

MOLECULAR WEIGHT :: 256.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 43841 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,117,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25125 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,117,1987

石杉碱甲B

石杉碱甲B用途

石杉碱甲B名称

石杉碱甲B生物活性

石杉碱甲B物理化学性质

石杉碱甲B毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

石杉碱甲B合成路线

详细合成路线

石杉碱甲B上下游产品

石杉碱甲B上游产品

石杉碱甲B下游产品

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