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4-氯氯苄

4-氯氯苄用途

可用于有机合成中间体，医药工业，染料工业。

4-氯氯苄名称

[ CAS 号 ]:
104-83-6

[ 中文名 ]:
4-氯氯苄

[ 英文名 ]:
4-Chlorobenzyl chloride

[中文别名 ]:

[英文别名 ]:

Benzene, 1-chloro-4- (chloromethyl)-
4-Chlorobenzyl chloride
EINECS 203-242-7
MFCD00000914
4-Chlorobenzylchloride
Toluene, p,α-dichloro-
Benzene, 1-chloro-4-(chloromethyl)-
α,4-Dichlorotoluene
1-Chloro-4-(chloromethyl)benzene
p-α-Dichlorotoluene

4-氯氯苄物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
223.0±0.0 °C at 760 mmHg

[ 熔点 ]:
27-29 °C(lit.)

[ 分子式 ]:
C₇H₆Cl₂

[ 分子量 ]:
161.029

[ 闪点 ]:
97.8±0.0 °C

[ 精确质量 ]:
159.984650

[ LogP ]:
3.08

[ 外观性状 ]:
无色液体

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.547

[ 储存条件 ]:
库房通风低温干燥,与含水物品分开储运

[ 水溶解性 ]:
insoluble

4-氯氯苄MSDS

4-氯氯苄毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XT0720000

CHEMICAL NAME :: Toluene, p,alpha-dichloro-

CAS REGISTRY NUMBER :: 104-83-6

BEILSTEIN REFERENCE NO. :: 0471558

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C7-H6-Cl2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1075 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 55(5),13,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1156 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 55(5),13,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 5625 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 55(5),13,1990 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10370 mg/kg/9W-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Blood - pigmented or nucleated red blood cells Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 55(5),13,1990 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83213 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 249 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83213 No. of Facilities: 43 (estimated) No. of Industries: 3 No. of Occupations: 21 No. of Employees: 5959 (estimated) No. of Female Employees: 763 (estimated)

4-氯氯苄安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332-H317-H411

[ 警示性声明 ]:
P273-P280

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R20/21/22;R34;R51/53

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S29-S61

[ 危险品运输编码 ]:
UN 3427 6.1/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
XT0720000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2903999090

4-氯氯苄合成路线

4-氯氯苄上下游产品

4-氯氯苄上游产品

4-氯氯苄下游产品

4-氯氯苄制备

1.氯苄低温氯化法氯化反应在硫磺和铁粉存在下进行。硫磺与铁粉比为9：1，反应温度15 -17℃ ，反应液相对密度增至1.22时，氯化结束。所得粗品经减压蒸馏而得成品，收率（按氯苄计）80.8%，含量94.4%。

2.对氯甲苯高温氯化法先将对氯甲苯投入反应器中，在 100℃ 开始缓慢通氯氯化，以后温度升至 115℃ 左右将所得对氯氯苄粗品经水洗，减压蒸馏，收集110 -120℃ （97.325kPa）馏分即为成品。

3.由氯苯与氯化氢、多聚甲醛等反应而得将氯苯、多聚甲醛、磷酸、氯化锌混合，通入氯化氢反应，温度为40 -45℃ ，反应时间约2h。然后用苯提取，碳酸钠中和，干燥，提纯而得成品。此外，对氯甲苯在偶氮二异丁腈的催化下经光照氯化而得。

4.制法：

于装有温度计、回流冷凝器(顶部连一氯化钙干燥管，干燥管连接氯化氢和氯气吸收装置)、通气导管的反应瓶中，加入对氯甲苯(2)100g（0.79mol），偶氮二异丁腈0.25g，加热回流。搅拌下通入氯气，开始时可通入的稍慢，随后可加快通氯速度，接近终点时可再慢一些。感应结束后冷却，减压蒸出未反应的氯和生成的氯化氢。加入无水碳酸钠粉末以中和反应体系中的酸，直至无二氧化碳气体逸出。过滤，减压蒸馏除去低沸物，得对氯苄基氯(1)，收率90%。

4-氯氯苄海关

[ 海关编码 ]: 2903999090

[ 中文概述 ]:
2903999090 其他芳烃卤化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

4-氯氯苄文献

Tonic inhibition of thermoregulation in the decerebrate monkey (Saimiri sciureus).

Exp. Neurol. 64(3) , 632-48, (1979)

Tetrahedron 50 , 4087, (1994)

Synth. Commun. 24 , 2247, (1994)

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