环丙基[4-[3-(1H-咪唑-5-基)丙氧基]苯基]甲酮盐酸盐

Ciproxifan belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.

[ 分子式 ]:
C₁₆H₁₉ClN₂O₂

[ 分子量 ]:
306.78700

[ 精确质量 ]:
306.11400

[ PSA ]:
54.98000

[ LogP ]:
3.81600

[ 外观性状 ]:
固体

[ 储存条件 ]:
2-8°C

详细MSDS(安全技术说明书)

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

Ciproxifan differentially modifies cognitive impairment evoked by chronic stress and chronic corticosterone administration in rats.

Behav. Brain Res. 283 , 145-53, (2015)

Despite the development of neuroscience and spectacular discoveries, the clear functions and the role of histamine are still not fully understood, especially in the context of the negative impact of p...

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：环丙基[4-[3-(1H-咪唑-5-基)丙氧基]苯基]甲酮盐酸盐

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥1354.0/5mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁

产品详情：盐酸环丙沙​​星

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