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克林沙星

克林沙星用途

Clinafloxacin(PD-127391)是氟喹诺酮抗生素。

克林沙星名称

[ CAS 号 ]:
105956-97-6

[ 中文名 ]:
克林沙星

[ 英文名 ]:
Clinafloxacin

[中文别名 ]:

罗非考昔

[英文别名 ]:

MFCD00865120
Clinafloxacin

克林沙星生物活性

[ 描述 ]:

Clinafloxacin(PD-127391)是氟喹诺酮抗生素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Humphrey, G.H., et al., Pharmacokinetics of clinafloxacin enantiomers in humans. J Clin Pharmacol, 1999. 39(11): p. 1143-50.

[2]. Pan, X.S. and L.M. Fisher, DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae. Antimicrob Agents Chemother, 1998. 42(11): p. 2810-6.

[3]. Jorgensen, J.H., et al., Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother, 2000. 44(11): p. 2962-8.

[相关活性小分子]

克林沙星物理化学性质

[ 密度 ]:
1.573 g/cm3

[ 沸点 ]:
592.3ºC at 760 mmHg

[ 熔点 ]:
253-258ºC

[ 分子式 ]:
C₁₇H₁₇ClFN₃O₃

[ 分子量 ]:
365.78700

[ 闪点 ]:
312ºC

[ 精确质量 ]:
365.09400

[ PSA ]:
88.56000

[ LogP ]:
3.12980

[ 外观性状 ]:
白色至淡黄色结晶粉末

[ 蒸汽压 ]:
7.14E-15mmHg at 25°C

[ 折射率 ]:
1.684

[ 储存条件 ]:
2-8°C

克林沙星安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H361d

[ 警示性声明 ]:
P281

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
VB1800600

[ 海关编码 ]:
2933990090

克林沙星合成路线

详细合成路线

克林沙星海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

克林沙星文献

Pharmacokinetics of danofloxacin and N-desmethyldanofloxacin in adult horses and their concentration in synovial fluid.

J. Vet. Pharmacol. Ther. 38(2) , 123-9, (2015)

The objectives of this study were to investigate the pharmacokinetics of danofloxacin and its metabolite N-desmethyldanofloxacin and to determine their concentrations in synovial fluid after administr...

Accumulation of garenoxacin by Bacteroides fragilis compared with that of five fluoroquinolones.

J. Antimicrob. Chemother. 52(4) , 605-9, (2003)

Garenoxacin is a novel des-F(6)-quinolone with good anti-anaerobe activity. The accumulation of garenoxacin and five other quinolones in the presence and absence of a variety of efflux pump inhibitors...

Synthesis and antibacterial activity of novel pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid derivatives carrying the 3-cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl group as a C-10 substituent.

J. Med. Chem. 51 , 3238-49, (2008)

Novel pyrido[1,2,3- de][1,4]benzoxazine-6-carboxylic acid derivatives 5- 9 carrying a 3-cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl moiety at the C-10 position were synthesized and their in vi...

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