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银杏内酯J

银杏内酯J用途

Ginkgolide J 是银杏叶中非黄酮部分的主要成分,IC50 的范围为 12-54 µM,具有神经保护和抗神经元凋亡的能力。

银杏内酯J名称

[ CAS 号 ]:
107438-79-9

[ 中文名 ]:
银杏内酯 J

[ 英文名 ]:
Ginkgolide J

[中文别名 ]:

[英文别名 ]:

GinkgolideJ
Ginkgolid J
7beta-hydroxyginkgolide a

银杏内酯J生物活性

[ 描述 ]:

Ginkgolide J 是银杏叶中非黄酮部分的主要成分,IC50 的范围为 12-54 µM,具有神经保护和抗神经元凋亡的能力。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

[体内研究]

银杏内酯J(100μM)处理可减少培养的鸡胚神经元中血清剥夺(24h)或星形孢菌素(200nM,24h)处理诱导的细胞凋亡损伤[1]。

[参考文献]

[1]. Ahlemeyer B, et al. Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry. 2003 Jun; 36 Suppl 1:S8-14.

[2]. Sylvia Pietri, et al. Synthesis and Biological Studies of a New Ginkgolide C Derivative: Evidence That the Cardioprotective Effect of Ginkgolides Is Unrelated to PAF Inhibition. DRUG DEVELOPMENT RESEARCH. 2001.54:191-201.

银杏内酯J物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
760.4±60.0 °C at 760 mmHg

[ 熔点 ]:
41-42 °C

[ 分子式 ]:
C₂₀H₂₄O₁₀

[ 分子量 ]:
424.399

[ 闪点 ]:
273.6±26.4 °C

[ 精确质量 ]:
424.136932

[ PSA ]:
148.82000

[ LogP ]:
-0.68

[ 外观性状 ]:
白色结晶

[ 蒸汽压 ]:
0.0±5.8 mmHg at 25°C

[ 折射率 ]:
1.651

[ 储存条件 ]:
2-8°C，避光

银杏内酯JMSDS

详细MSDS(安全技术说明书)

银杏内酯J安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3.0

银杏内酯J文献

Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba.

Magn. Reson. Chem. 50(8) , 569-75, (2012)

The complete and unambiguous (1)H NMR assignments of ten marker constituents of Ginkgo biloba are described. The comprehensive (1)H NMR profiles (fingerprints) of ginkgolide A, ginkgolide B, ginkgolid...

Rapid analysis of terpene lactones in extract of Ginkgo biloba L. by high performance liquid chromatography.

Se Pu 18(5) , 394-7, (2000)

A new rapid analytical method was developed for the quantification of terpene lactones (bilobalide(BB) and ginkgolide A, B, C, J) in extract of Ginkgo biloba L. (EGb) using a liquid-liquid solvent ext...

Protection against beta-amyloid induced abnormal synaptic function and cell death by Ginkgolide J.

Neurobiol. Aging 30(2) , 257-65, (2009)

A new Ginkgo biloba extract P8A (TTL), 70% enriched with terpene trilactones, prevents A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices. This neu...

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