正丁胺

正丁胺用途

【用途一】
用于制医药、农药除草剂、染料、表面活性剂、橡胶加工助剂等
【用途二】
用作分析试剂、乳化剂和染料中间体，也用于制药工业及杀虫剂的合成
【用途三】
正丁胺是杀菌剂苯菌灵的中间体，也是正丁基异氰酸酯的原料，用于生产磺酰脲类除草剂。
【用途四】
医药中间体，用于抗糖尿病药物的生产；农药中间体，用于氨基甲酸酯类除草剂、杀虫剂的生产；助剂中间体，用于制取裂化汽油的防胶剂、添加剂、汽油抗氧剂、橡胶阻聚剂、硅氧烷弹性体硫化剂、肥皂乳化剂；用正丁胺中和载色剂的酸度可控制醇酸和尿素磁漆的粘度；正丁胺的脂肪酸皂是有色金属浮选剂；正丁胺也是彩色相片的显影剂。美国大陆石油公司用正丁胺作脱蜡的选择性溶剂及原油破乳的表面张力抑制剂。
【用途五】
检验氰化物及某些铂金属。工业上用于生产医药、农药、染料、矿物浮选剂、乳化剂以及精细化学品的中间体等。

正丁胺名称

[ CAS 号 ]:
109-73-9

[ 中文名 ]:
正丁胺

[ 英文名 ]:
n-butylamine

[中文别名 ]:

[英文别名 ]:

n-Butylamine
EINECS 203-699-2
MFCD00011690
Butylamine
butan-1-amine
1-AMINO-BUTANE
1-aminobutane
1-butylamine
butyl amine
1-Butanamine

正丁胺物理化学性质

[ 密度 ]:
0.7±0.1 g/cm3

[ 沸点 ]:
77.3±3.0 °C at 760 mmHg

[ 熔点 ]:
−49 °C(lit.)

[ 分子式 ]:
C₄H₁₁N

[ 分子量 ]:
73.137

[ 闪点 ]:
-14.4±0.0 °C

[ 精确质量 ]:
73.089149

[ PSA ]:
26.02000

[ LogP ]:
0.93

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
2.5 (vs air)

[ 蒸汽压 ]:
97.3±0.1 mmHg at 25°C

[ 折射率 ]:
1.406

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Incompatible with oxidizing agents, aluminium, copper, copper alloys, acids. Highly flammable.

[ 水溶解性 ]:
MISCIBLE

正丁胺MSDS

详细MSDS(安全技术说明书)

正丁胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EO2975000

CHEMICAL NAME :: Butylamine

CAS REGISTRY NUMBER :: 109-73-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 49

MOLECULAR FORMULA :: C4-H11-N

MOLECULAR WEIGHT :: 73.16

WISWESSER LINE NOTATION :: Z4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 366 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - coma Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 629 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 198 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 850 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 590 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

MUTATION DATA

TEST SYSTEM :: Rodent - rat

REFERENCE :: ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7. Volume(issue)/page/year: 86,47,1976 *** REVIEWS *** ACGIH TLV-CL 15 mg/m3 (5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:air-CL 5 ppm (15 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,32,1971 OSHA PEL (Gen Indu):CL 5 ppm (15 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):CL 5 ppm (15 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):CL 5 ppm (15 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 5 ppm (15 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (15 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 5 ppm (15 mg/m3);Skin JAN 1993 OEL-BELGIUM:STEL 5 ppm (15 mg/m3);Skin JAN 1993 OEL-DENMARK:STEL 5 ppm (15 mg/m3);Skin JAN 1993 OEL-FINLAND:STEL 5 ppm (15 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 5 ppm (15 mg/m3) JAN 1993 OEL-GERMANY:TWA 5 ppm (15 mg/m3);Skin JAN 1993 OEL-JAPAN:STEL 5 ppm (15 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (15 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (15 mg/m3);Skin JAN 1993 OEL-RUSSIA:STEL 5 ppm (10 mg/m3);Skin JAN 1993 OEL-SWEDEN:STEL 5 ppm (15 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (15 mg/m3);STEL 25 ppm (75 mg/m3);Skin JAN 1993 OEL-THAILAND:TWA 5 ppm (15 mg/m3) JAN 1993 OEL-TURKEY:TWA 5 ppm (15 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (15 mg/m3);STEL 5 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO BUTYLAMINE-air:CL 5 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 14440 No. of Facilities: 97 (estimated) No. of Industries: 4 No. of Occupations: 9 No. of Employees: 1168 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 14440 No. of Facilities: 20 (estimated) No. of Industries: 2 No. of Occupations: 1 No. of Employees: 414 (estimated) No. of Female Employees: 85 (estimated)

正丁胺安全信息

[ 符号 ]:

GHS02, GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H290-H302-H311 + H331-H314

[ 警示性声明 ]:
P210-P261-P280-P303 + P361 + P353-P305 + P351 + P338-P370 + P378

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R11;R20/21/22;R35

[ 安全声明 (欧洲) ]:
S3-S16-S26-S29-S36/37/39-S45

[ 危险品运输编码 ]:
UN 1125 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
EO2975000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
29211980

正丁胺合成路线

详细合成路线

正丁胺上下游产品

正丁胺上游产品

正丁胺下游产品

正丁胺制备

1、丁醇氨化法将正丁醇蒸气和氨在常压下，在170-200℃下，通过加热的氧化铝、氧化钼等催化剂进行反应生成丁胺混合液，然后将产物经精馏分离，可得一、二、三丁胺成品。

2、丁醇氯化、氨化法将乙醇、氨水及氯丁烷加入高压釜中，搅拌升温至85-95℃，压力约0.54-0.64MPa，保持6h，冷却，降压。将反应液加热，回收氨气，然后加入盐酸至pH=3-4，再回收乙醇，向此粗液中加入液碱至pH11-12，分出上层液，经蒸馏收集95℃以下馏分，得正丁胺成品，收率50%。原料消耗定额：氯丁烷（80%）3295kg/t、乙醇（95%）840kg/t、氨水（20%）1500kg/t、液氨546kg/t、盐酸（30%）1170kg/t、液碱（30%）4515kg/t、固碱1670kg/t。此外，本品也可直接用氯代正丁烷在乙醇中与氢氧化铵作用制得。

3、将丁醇、氨和氢气在170～200℃通过载体为白土的Cu-Ni催化剂，得到三种胺即正丁胺、二正丁胺和三正丁胺的混合物，将产物进行分馏而得到正丁胺、二正丁胺和三正丁胺的产品。反应方程式：C₄H₉OH+NH₃[H₂]→C₄H₉NH₂[C₄H₉OH]→(C₄H₉)₂NH[C₄H₉OH]→(C₄H₉)₃N
或用丁醇为原料，经与氯化氢反应生成氯丁烷，将含氨的乙醇、氨水和氯丁烷压入高压釜搅拌升温至85～95℃，压力为539～637kPa，保持6h，冷却，反应完毕，将反应液加热回收氨气，然后加入盐酸至pH＝3～4，再回收乙醇，于此粗液中加入碱液至pH＝11～12，分出上层液，经蒸馏收集95℃以下馏分为正丁胺产品。反应方程式：C₄H₉OH+HCl→C₄H₉Cl+H₂O
C₄H₉Cl+NH₃[C₂H₅OH]→CH₃(CH₂)₃NH₂+HCl

正丁胺海关

[ 海关编码 ]: 2921199090

[ 中文概述 ]:
2921199090 其他无环单胺及其衍生物及其盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

正丁胺文献

Investigation of the structure-selectivity relationships and van't Hoff analysis of chromatographic stereoisomer separations of unusual isoxazoline-fused 2-aminocyclopentanecarboxylic acids on Cinchona alkaloid-based chiral stationary phases.

J. Chromatogr. A. 1384 , 67-75, (2015)

The enantiomers of four unusual, rather rigid isoxazoline-fused 2-aminocyclopentanecarboxylic acids were directly separated on a quinine- or a quinidine-based zwitterionic ion-exchanger as chiral sele...

Preparation of amidated derivatives of carboxymethylcellulose.

Int. J. Biol. Macromol. 72 , 11-8, (2014)

Carboxymethylcellulose (CMC) was selected as substrate for amidation based on previous results described for monocarboxy cellulose (MCC) with the aim to prepare highly substituted products. In compari...

Distribution study of atorvastatin and its metabolites in rat tissues using combined information from UHPLC/MS and MALDI-Orbitrap-MS imaging.

Anal. Bioanal. Chem 406(19) , 4601-10, (2014)

The combination of ultrahigh-resolution mass spectrometry imaging (UHRMSI) and ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC/MS/MS) was used for the identifi...

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正丁胺