噻吩

噻吩用途

【用途一】
用于合成药物先锋霉素等，也用于生产染料、合成树脂、溶剂等
【用途二】
噻吩可用于制造染料、医药和树脂；合成新型广谱抗菌素先锋霉素；用于彩色影片制造及特技摄影；合成一些复杂的试剂；它是合成酚醛塑料和树脂的重要中间体。噻吩本身就是很好的脱蜡剂和油漆清洗剂。噻吩的衍生物具有多种药理活性。噻吩偶氮染料品种繁多，性能优异。噻吩的磺酰脲类衍生物是超高效、低毒的新型除草剂。其他衍生物还可作为杀虫剂、杀菌剂、动植物生长促进剂等。另外，噻吩的有些衍生物还是有机半导体的组成成分。总之，噻吩及其衍生物在药物工业、染料工业、农药工业、树脂工业、化学工业等方面均有十分重要的地位。
【用途三】
用于制取药物、染料等。
【用途四】
噻吩（110-02-1）是一种重要的有机化工原料，它的用途非常广泛。主要用于染料、医药和树脂。合成新型广谱抗菌素先锋霉素，是一种重要的医药化工助剂，还可应用于彩色影片制造及特技摄影，合成一种复杂的试剂，用于铀等金属的提取分离等。
【用途五】
用作溶剂、色谱分析标准物质，及用于有机合成 ,制造树脂、染料和药品。

噻吩名称

[ CAS 号 ]:
110-02-1

[ 中文名 ]:
噻吩

[ 英文名 ]:
Thiophene

[中文别名 ]:

[英文别名 ]:

Thiole
Thiacyclopentadiene
MFCD00005413
Thiofuran
EINECS 203-729-4

噻吩物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
84.2±9.0 °C at 760 mmHg

[ 熔点 ]:
-38ºC

[ 分子式 ]:
C₄H₄S

[ 分子量 ]:
84.140

[ 闪点 ]:
-1.1±0.0 °C

[ 精确质量 ]:
84.003372

[ PSA ]:
28.24000

[ LogP ]:
1.90

[ 外观性状 ]:
无色至淡黄色液体

[ 蒸汽密度 ]:
2.9 (vs air)

[ 蒸汽压 ]:
81.7±0.1 mmHg at 25°C

[ 折射率 ]:
1.537

[ 储存条件 ]:
Flammables area

[ 稳定性 ]:
Stable. Highly flammable. Incompatible with strong oxidizing agents, nitrates.

[ 水溶解性 ]:
INSOLUBLE

噻吩MSDS

详细MSDS(安全技术说明书)

噻吩毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XM7350000

CHEMICAL NAME :: Thiophene

CAS REGISTRY NUMBER :: 110-02-1

BEILSTEIN REFERENCE NO. :: 0103222

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C4-H4-S

MOLECULAR WEIGHT :: 84.14

WISWESSER LINE NOTATION :: T5SJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(2),57,1966

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2000 ppm/6H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 8,141,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(2),57,1966

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9500 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(2),57,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 830 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1089,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 mg/m3/24H/80D-C

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Endocrine - other changes

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 32(6),3,1967

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1010 mg/m3/6H/21W-I

TOXIC EFFECTS :: Liver - liver function tests impaired Endocrine - evidence of thyroid hyperfunction

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(2),57,1966

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1010 mg/m3/6H/21W-I

TOXIC EFFECTS :: Liver - liver function tests impaired Endocrine - evidence of thyroid hyperfunction

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(2),57,1966

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1010 mg/m3/6H/21W-I

TOXIC EFFECTS :: Liver - liver function tests impaired Endocrine - evidence of thyroid hyperfunction

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(2),57,1966 *** REVIEWS *** TOXICOLOGY REVIEW ATORAI A.P.I. Toxicological Review. (American Petroleum Institute, 2101 L St., NW, Washington, DC 20037) Volume(issue)/page/year: -,-,1948

噻吩安全信息

[ 符号 ]:

GHS02, GHS05, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302-H315-H318-H331-H335-H340-H350

[ 警示性声明 ]:
P201-P210-P261-P280-P305 + P351 + P338-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable;Xn:Harmful;

[ 风险声明 (欧洲) ]:
R11;R20/22;R36;R52/53

[ 安全声明 (欧洲) ]:
S16-S36/37/39-S61

[ 危险品运输编码 ]:
UN 2414

[ WGK德国 ]:
3

[ RTECS号 ]:
XM7350000

[ 包装等级 ]:
II

[ 危险类别 ]:
3.0

[ 海关编码 ]:
29349990

噻吩合成路线

详细合成路线

噻吩上下游产品

噻吩上游产品

噻吩下游产品

噻吩制备

噻吩存在于煤焦油和页岩油内，可利用粗苯洗涤产生的废酸作原料，在110-150℃水解，水解时生成的气体经水解精馏塔进入塔顶冷凝器，冷凝得到的精馏产物含噻吩约为15%-25%、二甲苯约50%-60%，还含苯、甲苯、甲基噻吩及一些未知物。每吨废酸约可提取10kg精馏产物。用固体氢氧化钠脱水后通过精馏精制，可得90%-95%含量的噻吩产品。化学合成噻吩，可用丁烷和硫为原料，丁烷先脱氢再与硫成环形成噻吩，在实验室制备中用1,4-二羰基化合物与三硫化二磷反应而得。

精制方法：一般的精制方法是将噻吩用稀盐酸、水分别洗涤后，氯化钙干燥，用90cm高的蒸馏塔进行蒸馏，可得纯度99%（mol）的制品。欲得高纯度产品可将工业噻吩用稀盐酸、氢氧化钠、蒸馏水分别洗涤，氯化钙干燥，再用柱高235cm，填有2.4mm不锈钢制的拉希环的蒸馏塔，在回流比为50:1的情况下进行常压蒸馏，收集中间馏分，分步结晶6次，然后在乙醇醋酸钠溶液中用氯化亚汞处理，所得之固体加盐酸加热回流，冷却后用戊烷萃取噻吩。戊烷溶液用氯化钙干燥后分馏，可得纯度很高的制品。

噻吩海关

[ 海关编码 ]: 29349990

噻吩文献

Structure-based drug design identifies polythiophenes as antiprion compounds.

Sci. Transl. Med. 7 , 299ra123, (2015)

Prions cause transmissible spongiform encephalopathies for which no treatment exists. Prions consist of PrP(Sc), a misfolded and aggregated form of the cellular prion protein (PrP(C)). We explore the ...

Ultra trace analysis of PAHs by designing simple injection of large amounts of analytes through the sample reconcentration on SPME fiber after magnetic solid phase extraction.

Talanta 147 , 59-62, (2015)

A simple solventless injection method was introduced based on the using of a solid-phase microextraction (SPME) fiber for injection of large amounts of the analytes extracted by the magnetic solid pha...

Two bisthienylethene-Ir(III) complexes showing acid/base-induced structural transformation and on-off luminescence switching in solution.

Dalton Trans. 44 , 21008-15, (2015)

Complexes [Ir(dfppy)2(pbdtiH)](PF6)·2CHCl3 (1-H) and [Ir(dfppy)2(pbdti)] (1) were synthesized by the reaction of bisthienylethene pbdtiH and an [Ir(dfppy)2Cl]2 dimer under neutral and basic conditions...

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噻吩