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2-甲氧基乙酸乙酯

2-甲氧基乙酸乙酯用途

【用途一】
用作纤维素脂、以及各种树脂、蜡、油的溶剂。

2-甲氧基乙酸乙酯名称

[ CAS 号 ]:
110-49-6

[ 中文名 ]:
乙二醇甲醚乙酸酯

[ 英文名 ]:
2-Methoxyethyl acetate

[中文别名 ]:

[英文别名 ]:

3-OXABUTYL ACETATE
glycoletheremacetate
Methyl Glycol Acetate
Ethylene glycol monomethyl ether acetate
1-Acetoxy-2-methoxyethane
Acetic Acid 2-Methoxyethyl Ester
EINECS 203-772-9
methyl cellosolve acetate
MFCD00008719
EM ACETATE

2-甲氧基乙酸乙酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
143.2±0.0 °C at 760 mmHg

[ 熔点 ]:
−65 °C(lit.)

[ 分子式 ]:
C₅H₁₀O₃

[ 分子量 ]:
118.131

[ 闪点 ]:
43.9±0.0 °C

[ 精确质量 ]:
118.062996

[ PSA ]:
35.53000

[ LogP ]:
-0.08

[ 外观性状 ]:
无色液体

[ 蒸汽压 ]:
5.4±0.2 mmHg at 25°C

[ 折射率 ]:
1.391

[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开存放

[ 水溶解性 ]:
水溶性：完全混溶；混溶：丙酮,甲醇

2-甲氧基乙酸乙酯MSDS

2-甲氧基乙酸乙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KL5950000

CHEMICAL NAME :: Ethanol, 2-methoxy-, acetate

CAS REGISTRY NUMBER :: 110-49-6

BEILSTEIN REFERENCE NO. :: 1700761

LAST UPDATED :: 199712

DATA ITEMS CITED :: 49

MOLECULAR FORMULA :: C5-H10-O3

MOLECULAR WEIGHT :: 118.15

WISWESSER LINE NOTATION :: 1VO2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 1000 mg/m3

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - cough Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - muscle weakness Kidney, Ureter, Bladder - renal function tests depressed

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3100 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 6 gm/m3/7H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - food intake (animal) Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5250 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 12500 mg/kg

SEX/DURATION :: male 25 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 gm/kg

SEX/DURATION :: male 25 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 9800 mg/kg

SEX/DURATION :: female 7-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 9800 mg/kg

SEX/DURATION :: female 6-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 149,339,1985 *** REVIEWS *** ACGIH TLV-TWA 24 mg/m3 (5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 25 ppm (120 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,159,1971 OSHA PEL (Gen Indu):8H TWA 25 ppm (120 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 25 ppm (120 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 25 ppm (120 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 25 ppm (120 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (24 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 5 ppm (24 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (24 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 25 ppm (120 mg/m3);STEL 40 ppm (180 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (24 mg/m3) JAN 1993 OEL-GERMANY:TWA 5 ppm (25 mg/m3);Skin JAN 1993 OEL-HUNGARY:TWA 25 mg/m3;STEL 50 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 5 ppm (24 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (24 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 25 ppm (120 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 100 mg/m3 JAN 1993 OEL-RUSSIA:TWA 5 ppm JAN 1993 OEL-SWEDEN:TWA 5 ppm (25 mg/m3);STEL 10 ppm (50 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (25 mg/m3);STEL 10 ppm (50 mg/m3);Skin JAN 1993 OEL-TURKEY:TWA 25 ppm (120 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (24 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO EGMEA-air:10H TWA 0.1 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 46935 No. of Facilities: 2907 (estimated) No. of Industries: 45 No. of Occupations: 49 No. of Employees: 20492 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 46935 No. of Facilities: 658 (estimated) No. of Industries: 20 No. of Occupations: 27 No. of Employees: 9892 (estimated) No. of Female Employees: 2801 (estimated)

2-甲氧基乙酸乙酯安全信息

[ 符号 ]:

GHS02, GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H302 + H312 + H332-H360FD

[ 警示性声明 ]:
P201-P280-P308 + P313

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R20/21/22;R60;R61

[ 安全声明 (欧洲) ]:
S53-S45

[ 危险品运输编码 ]:
UN 1189 3/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
KL5950000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
2915390090

2-甲氧基乙酸乙酯合成路线

2-甲氧基乙酸乙酯上下游产品

2-甲氧基乙酸乙酯上游产品

2-甲氧基乙酸乙酯下游产品

2-甲氧基乙酸乙酯制备

精制方法：用氯化钙、无水碳酸钠干燥后减压蒸馏。

2-甲氧基乙酸乙酯海关

[ 海关编码 ]: 2915390090

[ 中文概述 ]:
2915390090. 其他乙酸酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2915390090. esters of acetic acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:5.5%. General tariff:30.0%

2-甲氧基乙酸乙酯文献

Hydration structure of poly(2-methoxyethyl acrylate): comparison with a 2-methoxyethyl acetate model monomer.

J. Biomater. Sci. Polym. Ed. 21(14) , 1925-35, (2010)

We have previously reported the hydration structure of a poly(2-methoxyethyl acrylate) (PMEA) antithrombogenic material. In the present study, the hydration structure of a 2-methoxyethyl acetate (MEAc...

Survey of ethylene glycol ether exposures in Belgian industries and workshops.

Am. Ind. Hyg. Assoc. J. 48(8) , 671-6, (1987)

From 1983 onward, 2654 air samples from 336 different plants from the northern part of Belgium were analyzed for the presence of ethylene glycol ethers. One or more ethylene glycol ethers were detecte...

Toxicity review of ethylene glycol monomethyl ether and its acetate ester.

Crit. Rev. Toxicol. 30(3) , 307-45, (2000)

Ethylene glycol monomethyl ether (EGME) and its acetate ester (EGMEA) are highly flammable, colorless, moderately volatile liquids with very good solubility properties. They are used in paints, lacque...

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