2-丁炔-1,4-二醇

2-丁炔-1,4-二醇用途

【用途一】
初级镀镍光亮剂
【用途二】
用于生产丁烯二醇、丁二醇、γ-丁内酯等系列化工产品
【用途三】
用作有机合成中间体及仪表电镀用的材料
【用途四】
丁炔二醇可以制造丁烯二醇、丁二醇、正丁醇、二氢呋喃、四氢呋喃、γ-丁内酯、吡咯烷酮等一系列重要的有机产品，进一步可以制造合成塑料、合成纤维（尼龙-4）、人造革、医药、农药、溶剂（N-甲基吡咯烷酮）和防腐剂。丁炔二醇本身是良好的溶剂，在电镀工业中作光亮剂。
【用途五】
丁二烯合成的中间体，腐蚀抑制剂，电镀光亮剂，聚合催化剂，脱叶剂，氯烃稳定剂。

2-丁炔-1,4-二醇名称

[ CAS 号 ]:
110-65-6

[ 中文名 ]:
丁炔二醇

[ 英文名 ]:
2-Butine-1,4-diol

[中文别名 ]:

[英文别名 ]:

1,4-Butynediol
1,4-dihydroxy-2-butyne
But-2-in-1,4-diol
EINECS 203-788-6
2-Butyne-1,4-diol
But-2-yne-1,4-diol
2-Butine-1,4-diol
1,2-Dihydroxydimethylacetylene
MFCD01075157
BOZ

2-丁炔-1,4-二醇物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
238.0±8.0 °C at 760 mmHg

[ 熔点 ]:
54 °C

[ 分子式 ]:
C₄H₆O₂

[ 分子量 ]:
86.089

[ 闪点 ]:
152.2±0.0 °C

[ 精确质量 ]:
86.036781

[ PSA ]:
40.46000

[ LogP ]:
-1.10

[ 外观性状 ]:
白色至淡棕色固体或褐色-黄色水状的溶液

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.506

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Highly flammable solid. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong acids, strong bases.

[ 水溶解性 ]:
3740 g/L (20 ºC)

2-丁炔-1,4-二醇MSDS

详细MSDS(安全技术说明书)

2-丁炔-1,4-二醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ES0525000

CHEMICAL NAME :: 2-Butyne-1,4-diol

CAS REGISTRY NUMBER :: 110-65-6

BEILSTEIN REFERENCE NO. :: 1071237

LAST UPDATED :: 199712

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C4-H6-O2

MOLECULAR WEIGHT :: 86.10

WISWESSER LINE NOTATION :: Q2UU2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 105 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation Blood - other changes

REFERENCE :: HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 33(1-3),41,1968

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/m3/2H

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Blood - hemorrhage

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 7,13,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 52435 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 26,597,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 105 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation Blood - other changes

REFERENCE :: HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 33(1-3),41,1968

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/m3/2H

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Blood - hemorrhage

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 7,13,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation Blood - other changes

REFERENCE :: HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 33(1-3),41,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation Blood - other changes

REFERENCE :: HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 33(1-3),41,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1400 mg/kg/28D-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 12,117,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 364 mg/kg/26W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Metabolism (Intermediary) - other carbohydrates

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(1),37,1968

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1400 mg/kg/14D-I

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 43,87,1989

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 mg/m3/4H/26W-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Vascular - BP lowering not characterized in autonomic section Liver - liver function tests impaired

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 7,13,1965

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/m3/2H/30D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Blood - hemorrhage Related to Chronic Data - death

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 7,13,1965 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2524 No. of Facilities: 307 (estimated) No. of Industries: 7 No. of Occupations: 11 No. of Employees: 2173 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2524 No. of Facilities: 1139 (estimated) No. of Industries: 21 No. of Occupations: 20 No. of Employees: 16527 (estimated) No. of Female Employees: 4755 (estimated)

2-丁炔-1,4-二醇安全信息

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R21;R23/25;R34;R43;R48/22

[ 安全声明 (欧洲) ]:
S25-S26-S36/37/39-S45-S46

[ 危险品运输编码 ]:
UN 2716 6.1/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
ES0525000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2905399090

2-丁炔-1,4-二醇上下游产品

2-丁炔-1,4-二醇上游产品

2-丁炔-1,4-二醇下游产品

2-丁炔-1,4-二醇制备

1.采用乙炔甲醛合成法　含80%-90%的乙炔经压缩至0.4-0.5MPa的压力，预热至70-80℃，送至反应器，以丁炔酮为催化剂，和甲醛于110-112℃反应，得粗品。反应产物经浓缩、精制得成品，同时副产丙炔醇。

2.多聚甲醛常压溶剂法：以多聚甲醛为原料，以环乙酮等作溶剂，在催化剂乙炔铜存在下，向反应器中通入乙炔，保持温度115-120℃，待甲醛完全后转化后停止通乙炔，滤出催化剂，反应液经浓缩再结晶，可得结晶状丁炔二醇。

2-丁炔-1,4-二醇海关

[ 海关编码 ]: 2905399090

[ 中文概述 ]:
2905399090 其他二元醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2905399090 other diols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%