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哌嗪

哌嗪用途

哌嗪是一种驱虫药。

哌嗪名称

[ CAS 号 ]:
110-85-0

[ 中文名 ]:
哌嗪

[ 英文名 ]:
Piperazine

[中文别名 ]:

[英文别名 ]:

PIPERAZINE CHIPS
Hexahydropyrazine
Pyrazine hexahydride
Trimetazidine Hydrochloride Impurity G
1,4-diazacyclohexane
1,4-piperazine
Diethylenediamine
Piperazine
1,4-Diazacyclohexan
EINECS 203-808-3

哌嗪生物活性

[ 描述 ]:

哌嗪是一种驱虫药。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

与对照相比,哌嗪(0.01-0.1 mM)略微抑制线虫的发育。哌嗪(1μM)可降低线虫的总孵卵大小。哌嗪以剂量依赖性方式增加发育迟缓斑马鱼的百分比[1]。哌嗪是CO2捕获的有吸引力的溶剂,哌嗪的释放可能有助于其相对较高的CO2吸收率[2]。

[参考文献]

[1]. Racz PI, et al. Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds. Toxicol In Vitro. 2017 Oct;44:11-16.

[2]. Stowe HM, et al. First-principles assessment of CO2 capture mechanisms in aqueous piperazine solution. Phys Chem Chem Phys. 2016 Sep 14;18(36):25296-25307.

哌嗪物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
149.3±8.0 °C at 760 mmHg

[ 熔点 ]:
109-112 °C(lit.)

[ 分子式 ]:
C₄H₁₀N₂

[ 分子量 ]:
86.136

[ 闪点 ]:
49.7±10.2 °C

[ 精确质量 ]:
86.084396

[ PSA ]:
24.06000

[ LogP ]:
-1.17

[ 外观性状 ]:
针状白色或无色晶体

[ 蒸汽压 ]:
4.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.424

[ 储存条件 ]:
库房通风低温干燥,与酸分开存放

[ 稳定性 ]:
Stable. Hygroscopic. Light sensitive. Flammable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
150 g/L (20 ºC)

哌嗪MSDS

哌嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TK7800000

CHEMICAL NAME :: Piperazine

CAS REGISTRY NUMBER :: 110-85-0

BEILSTEIN REFERENCE NO. :: 0102555

LAST UPDATED :: 199704

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C4-H10-N2

MOLECULAR WEIGHT :: 86.16

WISWESSER LINE NOTATION :: T6M DMTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/16/1967

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,862,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Gastrointestinal - nausea or vomiting

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,478,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,116,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1340 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 103,414,1964

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5400 mg/m3/2H

TOXIC EFFECTS :: Behavioral - excitement Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,116,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PBPHAW Progress in Biochemical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1965- Volume(issue)/page/year: 1,542,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/16/1965 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND:TWA 1 mg/m3;STEL 5 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 0.1 ppm (0.3 mg/m3);STEL 0.3 ppm (1 mg/m3) JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84705 No. of Facilities: 132 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 2512 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84705 No. of Facilities: 435 (estimated) No. of Industries: 10 No. of Occupations: 25 No. of Employees: 8786 (estimated) No. of Female Employees: 2609 (estimated)

哌嗪安全信息

[ 符号 ]:

GHS05, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314-H317-H334-H361fd

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R34;R42/43;R52/53

[ 安全声明 (欧洲) ]:
S22-S26-S36/37/39-S45-S61

[ 危险品运输编码 ]:
UN 2579 8/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
TK7800000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2933599090

哌嗪合成路线

哌嗪上下游产品

哌嗪上游产品

哌嗪下游产品

哌嗪制备

1、由氯乙醇经氨化、环合成哌嗪盐酸盐，再用氢氧化钠中和制得六水哌嗪。

2、以氯乙醇为原料，经氨化、环合而得。其工艺是将氯乙醇和氢氧化铵在高压釜中升温到氨压达441 kPa，搅拌反应5h，常压回收过量的氢氧化铵得氨基乙醇水溶液。加入定量盐酸搅拌，减压浓缩成半糊状的乙醇胺盐酸盐浓缩液，升温去水至150℃，加入事先熔融好的石蜡，再继续升温到260℃，保持(260±2)℃反应12h，放料过滤，除去石蜡，即得盐酸哌嗪。将盐酸哌嗪、固体氢氧化钠、水加入反应釜内，搅拌1.5h，排氨，然后升温至130～140℃，蒸出六水哌嗪溶液，残渣滤去，六水哌嗪溶液冷冻至8℃，离心甩滤得六水哌嗪，六水哌嗪脱水即得哌嗪成品。反应方程式如：ClCH₂CH₂OH+NH₄OH→NH₂CH₂CH₂OH·HCl+H₂O

哌嗪海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

哌嗪文献

Polyoxometalates--potent and selective ecto-nucleotidase inhibitors.

Biochem. Pharmacol. 93(2) , 171-81, (2015)

Polyoxometalates (POMs) are inorganic cluster metal complexes that possess versatile biological activities, including antibacterial, anticancer, antidiabetic, and antiviral effects. Their mechanisms o...

Characterizing the structure of lipodisq nanoparticles for membrane protein spectroscopic studies.

Biochim. Biophys. Acta 1848(1 Pt B) , 329-33, (2015)

Membrane protein spectroscopic studies are challenging due to the difficulty introduced in preparing homogenous and functional hydrophobic proteins incorporated into a lipid bilayer system. Traditiona...

Mutations in intron 1 and intron 22 inversion negative haemophilia A patients from Western India.

PLoS ONE 9(5) , e97337, (2014)

Despite increased awareness and diagnostic facilities, 70-80% of the haemophilia A (HA) patients still remain undiagnosed in India. Very little data is available on prevalent mutations in HA from this...

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哌嗪