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1,10-癸二醇

1,10-癸二醇用途

【用途一】
用于制备香精香料
【用途二】
医药中间体。
【用途三】
1,10-癸二醇（112-47-0）用于生产双碘癸烷以制备抗细菌和抗霉菌药（双）克菌定和奥替尼啶等，并用于制备粘合剂、特种材料等

1,10-癸二醇名称

[ CAS 号 ]:
112-47-0

[ 中文名 ]:
1,10-癸二醇

[ 英文名 ]:
1,10-Decanediol

[中文别名 ]:

[英文别名 ]:

decane-1,10-diol
1,10-Decanediol
MFCD00004749
1,10-Dihydroxydecane
EINECS 203-975-2
Decamethylene glycol
1,10-Ddecanediol

1,10-癸二醇物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
305.4±10.0 °C at 760 mmHg

[ 熔点 ]:
70-73 °C

[ 分子式 ]:
C₁₀H₂₂O₂

[ 分子量 ]:
174.281

[ 闪点 ]:
141.7±13.6 °C

[ 精确质量 ]:
174.161987

[ PSA ]:
40.46000

[ LogP ]:
2.06

[ 外观性状 ]:
白色晶体或粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.458

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with oxidizing agents, acid chlorides, acid anhydrides, chloroformates, reducing agents.

[ 水溶解性 ]:
Insoluble

1,10-癸二醇MSDS

1,10-癸二醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HD8433713

CHEMICAL NAME :: 1,10-Decanediol

CAS REGISTRY NUMBER :: 112-47-0

BEILSTEIN REFERENCE NO. :: 1698975

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H22-O2

MOLECULAR WEIGHT :: 174.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,219,1954

1,10-癸二醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
HD8433713

[ 海关编码 ]:
29053980

1,10-癸二醇合成路线

1,10-癸二醇上下游产品

1,10-癸二醇上游产品

1,10-癸二醇下游产品

1,10-癸二醇制备

1.由癸二酸经酯化；还原而得。1.酯化将癸二酸；乙醇；苯；对甲苯磺酸加入装有水分离器的反应锅中，加热回流，带水约4-5h，至无水分分出为止，冷却过滤，得癸二酸二乙酯粗品。收率85%。2.还原先将癸二酸二乙酯及无水乙醇投入反应锅中，在搅拌及冷却下再将金属钠逐渐加入，加热回流到金属钠全部溶解，无残留物为止。进行水蒸汽蒸馏，回收乙醇，然后再加入水稀释，冷却，析出的粗品用苯重结晶即得成品，收率为54%。

2.制法：

于装有搅拌器、通气导管、回流冷凝器(装一只氯化钙干燥管)、滴液漏斗的干燥的反应瓶中，加入癸二酸二乙酯(2)65g(0.25mol),无水乙醇800mL。搅拌下冰水浴冷却。一次加入新鲜的、切成块的金属钠70g(3.0mol),反应剧烈进行，有氢气逸出。待反应平稳后，水浴加热，直至金属钠反应完全。稍冷后，加入水300mL，蒸出乙醇。最后减压蒸馏以除去残存的乙醇。加入热水600mL，静置冷却。分出油状物(水层保留)，冷后固化。固体物用少量水洗涤，真空干燥。固体物用苯提取四次(250mL×4),合并苯层，活性炭脱色。浓缩至60mL左右，加入200mL乙醇，过滤，再浓缩至60mL左右，加入等体积的苯，加热溶解。冷却，析出固体。抽滤，乙醚洗涤，得1，10-癸二醇(1)32g,mp72～74℃,收率73%。

1,10-癸二醇海关

[ 海关编码 ]: 2905399090

[ 中文概述 ]:
2905399090 其他二元醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2905399090 other diols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

1,10-癸二醇文献

[Bent dsDNA with defined geometric characteristics in terms of complexes of bridged oligonucleotides].

Bioorg. Khim. 35(3) , 384-96, (2009)

An opportunity of designing nontypical double-stranded DNA structures containing nonnatural inserts in a regular nucleotide DNA sequence has been investigated. The looped nucleotide inserts on the bas...

Development and applications of injectable poly(ortho esters) for pain control and periodontal treatment.

Biomaterials 23(22) , 4397-404, (2002)

Poly(ortho esters) with a low glass transition temperature are semi-solid materials so that therapeutic agents can be incorporated at room temperature, without the use of solvents, by a simple mixing ...

Synthesis and characterization of self-catalyzed poly(ortho-esters) based on decanediol and decanediol-lactate.

J. Biomater. Sci. Polym. Ed. 10(3) , 375-89, (1999)

The synthesis of poly(ortho-esters) (POEs) containing lactic acid dimers in the polymer backbone for possible use in controlled drug release applications is described. These autocatalyzed POEs are pre...

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