抗氧剂2246

抗氧剂2246用途

【用途一】
通用型酚类防老剂，广泛用于天然橡胶、合成橡胶、乳胶、其他多种合成材料和石油制品中作抗氧剂
【用途二】
抗氧化剂2246(2,2-亚甲基双-(4-甲基-6-叔丁基苯酚))是一种性能卓越的高效非污染型抗氧剂。在橡胶工业中, 抗氧化剂2246是合成橡胶, 胶乳和天然胶的抗氧剂, 是酚类抗氧剂中较优良的品种之一。加入抗氧化剂2246(119-47-1)的橡胶制品可抗热氧老化, 部分地防止光照臭氧老化和多次变形的破坏。并能钝化可变价金属的盐类。用于浅色和有色橡胶制品, 在塑料工业中, 抗氧化剂2246能阻止氯化聚醚, 耐冲击聚苯乙烯, ABS树脂, 聚甲醛, 纤维素树脂的热老化和光老化, 用量为0.5-1%

抗氧剂2246名称

[ CAS 号 ]:
119-47-1

[ 中文名 ]:
2,2'-亚甲基双-(4-甲基-6-叔丁基苯酚)

[ 英文名 ]:
2,2'-Methylenebis(6-tert-butyl-4-methylphenol)

[中文别名 ]:

[英文别名 ]:

MFCD00043641
Cyanox 2246
2,2'-Methylenebis(6-tert-butyl-p-cresol)
EINECS 204-327-1
p-Cresol, 2,2'-methylenebis[6-tert-butyl-
2,2'-Methylene-bis-(4-methyl-6-tert-butyl-phenol)
6,6'-Methylenebis(2-(tert-butyl)-4-methylphenol)
2,2'-methylenebis(6-tert-butyl-4-methylphenol)
Bis(3-tert-butyl-2-hydroxy-5-methylphenyl)methane
1X1&1&R BQ E1 C1R BQ E1 CX1&1&1

抗氧剂2246物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
428.6±40.0 °C at 760 mmHg

[ 熔点 ]:
123-127 °C(lit.)

[ 分子式 ]:
C₂₃H₃₂O₂

[ 分子量 ]:
340.499

[ 闪点 ]:
181.2±21.9 °C

[ 精确质量 ]:
340.240234

[ PSA ]:
40.46000

[ LogP ]:
7.03

[ 外观性状 ]:
白色至淡奶油色结晶粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.551

[ 储存条件 ]:
室温，干燥

抗氧剂2246MSDS

详细MSDS(安全技术说明书)

抗氧剂2246毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PA3500000

CHEMICAL NAME :: Methane, 2,2'-bis(6-t-butyl-p-cresyl)-

CAS REGISTRY NUMBER :: 119-47-1

BEILSTEIN REFERENCE NO. :: 2062676

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C23-H32-O2

MOLECULAR WEIGHT :: 340.55

WISWESSER LINE NOTATION :: 1X1&1&R BQ C3R BQ CX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,240,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 38(8),28,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19,77,1994 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1623 mg/kg/1W-C

TOXIC EFFECTS :: Liver - other changes Blood - changes in other cell count (unspecified) Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 8,77,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25200 mg/kg/12W-C

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19,77,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23096 mg/kg/78W-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19,77,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82995 No. of Facilities: 275 (estimated) No. of Industries: 6 No. of Occupations: 23 No. of Employees: 5131 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82995 No. of Facilities: 6941 (estimated) No. of Industries: 70 No. of Occupations: 72 No. of Employees: 150745 (estimated) No. of Female Employees: 36237 (estimated)

抗氧剂2246安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H361f-H413

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
PA3500000

[ 海关编码 ]:
29072900

抗氧剂2246合成路线

详细合成路线

抗氧剂2246上下游产品

抗氧剂2246上游产品

抗氧剂2246下游产品

抗氧剂2246制备

对甲酚在732#强酸性离子交换树脂的催化下，于60℃左右，与异丁烯进行烷基化反应。反应结束后，滤去催化剂，将滤液加入甲醇-烧碱溶液中，析出防老剂264。过滤后，将防老剂264在酒精中重结晶，再过滤、干燥，即得副产物防老剂264。滤去防老剂264后的滤液，经中和、蒸馏（回收甲醇）、水洗、减压蒸馏、结晶、过滤，即得中间产品2-叔丁基-4-甲酚。将此中间体以200#汽油为溶剂与甲醛在硫酸介质中，于90～95℃进行缩合反应。反应产物经中和、过滤、洗涤、干燥、打粉、包装，即得成品。

抗氧剂2246海关

[ 海关编码 ]: 29072900

抗氧剂2246文献

Bis(2-hydroxy-3-tert-butyl-5-methyl-phenyl)-methane (bis-phenol) is a potent and selective inhibitor of the secretory pathway Ca²⁺ ATPase (SPCA1).

Biochem. Biophys. Res. Commun. 424(3) , 616-9, (2012)

The secretory pathway Ca(2+) ATPase (SPCA) provides the Golgi apparatus with a Ca(2+) supply essential for Ca(2+)-dependent enzymes involved in the post-translational modification of proteins in trans...

Effects of four bisphenolic antioxidants on lipid contents of rat liver.

Toxicol. Lett. 8(1-2) , 77-86, (1981)

Hepatic lipids were studied in Sprague-Dawley male rats given, 2,2'-methylenebis(4-ethyl-6-tert-butylphenol), 2,2'-methylenebis(4-methyl-6-tert-butylphenol), 4,4'-butylidenebis(3-methyl-6-tert-butylph...

Inhibition of the sarcoplasmic and endoplasmic calcium pump by bis(2-hydroxy-3-tert-butyl-5-methyl)methane, (bis-phenol).

Biochem. Soc. Trans. 21(2) , 106S, (1993)

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