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二苯甲酮

二苯甲酮用途

Benzophenone 是一种内源性代谢产物。

二苯甲酮名称

[ CAS 号 ]:
119-61-9

[ 中文名 ]:
二苯甲酮

[ 英文名 ]:
Benzophenone

[中文别名 ]:

[英文别名 ]:

Diphenylmethanone
Kayacure BP
Benzophenone
RVR
MFCD00003076
Diphenylketone
α-Oxoditane
Methanone, diphenyl-
α-Oxodiphenylmethane
A-Oxodiphenylmethane

二苯甲酮生物活性

[ 描述 ]:

Benzophenone 是一种内源性代谢产物。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

二苯甲酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
305.4±0.0 °C at 760 mmHg

[ 熔点 ]:
47-51 °C(lit.)

[ 分子式 ]:
C₁₃H₁₀O

[ 分子量 ]:
182.218

[ 闪点 ]:
123.7±13.7 °C

[ 精确质量 ]:
182.073166

[ PSA ]:
17.07000

[ LogP ]:
3.18

[ 外观性状 ]:
橙色晶体

[ 蒸汽密度 ]:
4.21 (vs air)

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.584

[ 储存条件 ]:
通风低温干燥

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong reducing agents. Combustible.

[ 水溶解性 ]:
insoluble (

二苯甲酮MSDS

详细MSDS(安全技术说明书)

二苯甲酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DI9950000

CHEMICAL NAME :: Benzophenone

CAS REGISTRY NUMBER :: 119-61-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C13-H10-O

MOLECULAR WEIGHT :: 182.23

WISWESSER LINE NOTATION :: RVR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,873,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2895 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - other changes

REFERENCE :: EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9. Volume(issue)/page/year: 9,99,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 727 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - other changes

REFERENCE :: EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9. Volume(issue)/page/year: 9,99,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3535 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,873,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14 gm/kg/28D-C

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 29,741,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 91 gm/kg/13W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 14,221,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 109 gm/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 14,221,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 75 mg/kg/15D-I

TOXIC EFFECTS :: Liver - other changes Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring)

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 50,282,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83170 No. of Facilities: 1495 (estimated) No. of Industries: 8 No. of Occupations: 11 No. of Employees: 6944 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83170 No. of Facilities: 1809 (estimated) No. of Industries: 27 No. of Occupations: 50 No. of Employees: 41516 (estimated) No. of Female Employees: 18162 (estimated)

二苯甲酮安全信息

[ 符号 ]:

GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H351-H410

[ 警示性声明 ]:
P273-P281-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38;R50/53

[ 安全声明 (欧洲) ]:
S26-S61-S37/39-S29-S60-S36-S62-S36/37-S33-S16-S9

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
DI9950000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

[ 海关编码 ]:
2914399090

二苯甲酮上下游产品

二苯甲酮上游产品

二苯甲酮下游产品

二苯甲酮制备

1.由氯苄经与苯缩合，再经硝酸氧化而得。

2.由苯经与四氯化碳缩合，再经水解而得。在实验室中，是以三氯化铝作催化剂，使苯与苯甲酰氯反应制备。

将干燥的苯和新蒸过的苯甲酰氯混合后，加入粉状无水三氯化铝。加热回流3h至无氯化氢放出为止。趁热倒入冰水和浓盐酸的混合液中，分层；取上层用5%氢氧化钠溶液洗涤，再用水洗涤。回收苯后用无水硫酸镁干燥，减压蒸馏得二苯甲酮。

3.将苯和氯化锌催化剂混合均匀，控制压力为174～348Pa ，在搅拌下加热到70～75℃，反应10h之后，静置分层，取上层油状物用清水洗涤二次，除去氯化锌及盐酸。再用１％的稀碱液洗涤一次，蒸馏除去苯及150℃以下馏分。在所得的二苯甲烷粗品中加入碎片或沸石，搅拌加热至100～115℃，边搅拌边缓慢滴加70%的硝酸，然后于106～116℃保温8h。分层后取油层分别用热水、３％碳酸钠洗涤3次，最后减压蒸馏，收集145～180℃ （ 667～1200Pa）或160～210℃（ 1333～2400 Pa）馏分，即为成品。
过程反应式：

4.先将3倍苯量的四氯化碳和三氯化铝混合物冷却到10～15℃，加入苯，继续冷却至5～10℃，然后滴加四氯化碳：苯＝1∶ 6（摩尔比）的二组分混合液（其中苯的量为前一次加入苯量的11倍），控制滴加速度，使反应温度维持在5～10℃，并于10℃下反应3h。之后，加入适量水，搅拌均匀，加
热蒸馏，先蒸出过量四氯化碳，再升温进行水蒸气蒸馏，保证水蒸气蒸馏时间，使水解反应完全，并使产物一并蒸出。静置，水层用苯液萃取，萃取液并入油层，然后使油层结晶，过滤后，加热结晶，熔融并减压蒸馏，收集157～176℃ （1333～2666Pa）馏分，即为成品。
过程反应式：

5.苯甲酸钙热分解法　首先制得苯甲酸钙，再由苯甲酸钙粉解制得。为新开发的二苯甲酮的绿色合成路线。
①流变相法合成苯甲酸钙　称取一定量的摩尔比为１∶２的碳酸钙和苯甲酸，将两者混合均匀，加水调成流变态，移入反应器，控制温度在１００℃反应８ｈ。将产物用乙醚洗涤三次，然后置于干燥箱中于２４０℃干燥，即得无水苯甲酸钙。

②苯甲酸钙在氮气中热分解，收集500℃的分解产物得碳酸钙和二苯甲酮等产物。碳酸钙进一步分解生成氧化钙。

二苯甲酮海关

[ 海关编码 ]: 2914399090

[ 中文概述 ]:
2914399090. 其他不含其他含氧基的芳香酮. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

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