N-(4-羟基苯基)乙酰胺

N-(4-羟基苯基)乙酰胺用途

N-Acetyltyramine 是溶藻弧菌 M3-10 产生的群体感应抑制剂 (QSI) 化合物。N-Acetyltyramine 能抑制 C. violaceum ATCC 12472 的群体感应 (QS)。N-Acetyltyramine 逆转阿霉素耐药白血病 P388 细胞的耐药性。

N-(4-羟基苯基)乙酰胺名称

[ CAS 号 ]:
1202-66-0

[ 中文名 ]:
N-乙酰基酪胺

[ 英文名 ]:
N-Acetyltyramine

[中文别名 ]:

[英文别名 ]:

GNF-PF-5230
N-Acetyltyramine
N-acetyltyramin
N-[2-(4-Hydroxyphenyl)ethyl]acetamide
Acetamide, N-[2-(4-hydroxyphenyl)ethyl]-

N-(4-羟基苯基)乙酰胺生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[体外研究]

N-乙酰酪胺增强了耐药P388小鼠白血病细胞中阿霉素的细胞毒性,IC50值为0.13μg/ml,而单用阿霉素的IC50值为0.48µg/ml[2]。

[参考文献]

[1]. Reina JC, et al. A Quorum-Sensing Inhibitor Strain of Vibrio alginolyticus Blocks Qs-Controlled Phenotypes in Chromobacterium violaceum and Pseudomonas aeruginosa. Mar Drugs. 2019;17(9):494. Published 2019 Aug 24.

[2]. Kunimoto S, et al. Reversal of resistance by N-acetyltyramine or N-acetyl-2-phenylethylamine in doxorubicin-resistant leukemia P388 cells. J Antibiot (Tokyo). 1987;40(11):1651-1652.

N-(4-羟基苯基)乙酰胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
424.1±28.0 °C at 760 mmHg

[ 熔点 ]:
134°C

[ 分子式 ]:
C₁₀H₁₃NO₂

[ 分子量 ]:
179.216

[ 闪点 ]:
210.3±24.0 °C

[ 精确质量 ]:
179.094635

[ PSA ]:
49.33000

[ LogP ]:
0.39

[ 外观性状 ]:
灰白色

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.546

[ 储存条件 ]:
2-8°C

N-(4-羟基苯基)乙酰胺MSDS

N-(4-羟基苯基)乙酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC3852300

CHEMICAL NAME :: Acetamide, N-(2-(4-hydroxyphenyl)ethyl)-

CAS REGISTRY NUMBER :: 1202-66-0

BEILSTEIN REFERENCE NO. :: 2096467

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H13-N-O2

MOLECULAR WEIGHT :: 179.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Cardiac - cardiomyopathy including infarction Skin and Appendages - hair

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 38,474,1976

N-(4-羟基苯基)乙酰胺安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2924299090

N-(4-羟基苯基)乙酰胺合成路线

N-(4-羟基苯基)乙酰胺上下游产品

N-(4-羟基苯基)乙酰胺上游产品

N-(4-羟基苯基)乙酰胺下游产品

N-(4-羟基苯基)乙酰胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-(4-羟基苯基)乙酰胺文献

Selective nanomolar detection of dopamine using a boron-doped diamond electrode modified with an electropolymerized sulfobutylether-beta-cyclodextrin-doped poly(N-acetyltyramine) and polypyrrole composite film.

Anal. Chem. 81(10) , 4089-98, (2009)

N-acetyltyramine was synthesized and electropolymerized together with a negatively charged sulfobutylether-beta-cyclodextrin on a boron-doped diamond (BDD) electrode followed by the electropolymerizat...

Mechanistic and structural analysis of Drosophila melanogaster arylalkylamine N-acetyltransferases.

Biochemistry 53(49) , 7777-93, (2014)

Arylalkylamine N-acetyltransferase (AANAT) catalyzes the penultimate step in the biosynthesis of melatonin and other N-acetylarylalkylamides from the corresponding arylalkylamine and acetyl-CoA. The N...

Effect of acetyl derivatives of some sympathomimetic amines on the blood pressure of the rat.

Acta Pharmacol. Toxicol. (Copenh.) 40(2) , 247-58, (1977)

The effect of five sympathomimetic amines and some of their acetyl derivatives on the blood pressure of the rat was determined on the left carotid artery. After pretreatment with chlorisondamine (1 mg...

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