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4-氯-3-磺酰胺基苯甲酸

4-氯-3-磺酰胺基苯甲酸用途

用于医药合成

4-氯-3-磺酰胺基苯甲酸名称

[ CAS 号 ]:
1205-30-7

[ 中文名 ]:
4-氯-3-磺酰胺基苯甲酸

[ 英文名 ]:
4-Chloro-3-sulfamoylbenzoic acid

[中文别名 ]:

[英文别名 ]:

Benzoic acid, 3-(aminosulfonyl)-4-chloro-
EINECS 214-882-1
4-Chloro-3-sulfamoylbenzoic acid
MFCD00012375
3-(aminosulfonyl)-4-chlorobenzoic acid

4-氯-3-磺酰胺基苯甲酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
502.4±60.0 °C at 760 mmHg

[ 熔点 ]:
256-258 °C(lit.)

[ 分子式 ]:
C₇H₆ClNO₄S

[ 分子量 ]:
235.645

[ 闪点 ]:
257.6±32.9 °C

[ 精确质量 ]:
234.970612

[ PSA ]:
105.84000

[ LogP ]:
0.92

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.622

[ 储存条件 ]:
Refrigerator

4-氯-3-磺酰胺基苯甲酸MSDS

4-氯-3-磺酰胺基苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG5642600

CHEMICAL NAME :: Benzoic acid, 4-chloro-3-sulfamoyl-

CAS REGISTRY NUMBER :: 1205-30-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H6-Cl-N-O4-S

MOLECULAR WEIGHT :: 235.65

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,2275,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,2275,1982

4-氯-3-磺酰胺基苯甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DG5642600

4-氯-3-磺酰胺基苯甲酸合成路线

4-氯-3-磺酰胺基苯甲酸上下游产品

4-氯-3-磺酰胺基苯甲酸上游产品

4-氯-3-磺酰胺基苯甲酸下游产品

4-氯-3-磺酰胺基苯甲酸文献

Studies on metabolism of tripamide. III. Metabolic fate of 14C-tripamide in rats and rabbits.

Jpn. J. Pharmacol. 32(6) , 1041-9, (1982)

The metabolic fate of a new antihypertensive agent, tripamide (N-(4-aza-endo-tricyclo[5.2.1.0(2,6))]-decan-4-yl)-4-chloro-3-sulfamoylbenzamide), in rats and rabbits was studied using its 14C-labeled c...

Chromatographic-densitometric Method for Determination of Clopamide and 4-chlorobenzoic, and 4-chloro-3-sulfamoylbenzoic Acids in Tablets. Hubicka U, et al.

Curr. Pharm. Anal. 5(4) , 408-15, (2009)

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