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左美丙嗪盐酸盐

左美丙嗪盐酸盐名称

[ CAS 号 ]:
1236-99-3

[ 中文名 ]:
左美丙嗪盐酸盐

[ 英文名 ]:
Levomepromazine hydrochloride

[中文别名 ]:

[英文别名 ]:

methotrimeprazine hydrochloride
Levopromazine hydrochloride
Einecs 214-978-3
Levomepromazinium chloride
7044 Rp hydrochloride
LevomepromazineHCl

左美丙嗪盐酸盐物理化学性质

[ 沸点 ]:
468ºC at 760 mmHg

[ 分子式 ]:
C₁₉H₂₅ClN₂OS

[ 分子量 ]:
364.93300

[ 闪点 ]:
236.8ºC

[ 精确质量 ]:
364.13800

[ PSA ]:
41.01000

[ LogP ]:
5.36260

[ 蒸汽压 ]:
6.22E-09mmHg at 25°C

[ 储存条件 ]:
2-8°C

左美丙嗪盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO6150000

CHEMICAL NAME :: Phenothiazine, 10-(3-(dimethylamino)-2-methylpropyl)-2-methoxy-, hydrochloride

CAS REGISTRY NUMBER :: 1236-99-3

LAST UPDATED :: 199707

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H24-N2-O-S.Cl-H

MOLECULAR WEIGHT :: 364.97

WISWESSER LINE NOTATION :: T C666 BN ISJ B1Y1&1N1&1 EO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 15,455,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 160,1852,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 155,1029,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Behavioral - sleep

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,87,1962