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盐酸硫利达嗪

盐酸硫利达嗪用途

Thioridazine是一种治疗精神类疾病的药物, 如精神分裂症, 具有多巴胺D4受体选择性和5-羟色胺拮抗作用。

盐酸硫利达嗪名称

[ CAS 号 ]:
130-61-0

[ 中文名 ]:
盐酸硫利达嗪

[ 英文名 ]:
Thioridazine hydrochloride

[中文别名 ]:

盐酸硫代利哒

[英文别名 ]:

Thioridazine hydrochloride
EINECS 204-992-8
MFCD00012655
Novoridazine
Stalleril
Sonapax

盐酸硫利达嗪生物活性

[ 描述 ]:

Thioridazine是一种治疗精神类疾病的药物, 如精神分裂症, 具有多巴胺D4受体选择性和5-羟色胺拮抗作用。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

信号通路 >> 自噬 >> 自噬

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[相关活性小分子]

盐酸硫利达嗪物理化学性质

[ 沸点 ]:
515.7ºC at 760 mmHg

[ 熔点 ]:
158-1600C

[ 分子式 ]:
C₂₁H₂₇ClN₂S₂

[ 分子量 ]:
407.035

[ 闪点 ]:
265.7ºC

[ 精确质量 ]:
406.130432

[ PSA ]:
57.08000

[ LogP ]:
6.69050

[ 外观性状 ]:
白色至灰白色固体

[ 蒸汽压 ]:
9.65E-11mmHg at 25°C

[ 储存条件 ]:
Desiccate at RT

盐酸硫利达嗪MSDS

详细MSDS(安全技术说明书)

盐酸硫利达嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SP2275000

CHEMICAL NAME :: Phenothiazine, 10-(2-(1-methyl-2-piperidyl)ethyl)-2-(methylthio)-, monohydrochloride

CAS REGISTRY NUMBER :: 130-61-0

LAST UPDATED :: 199707

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C21-H26-N2-S2.Cl-H

MOLECULAR WEIGHT :: 407.07

WISWESSER LINE NOTATION :: T C666 BN ISJ ES1 B2- BT6NTJ A1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 864 mg/kg/18D-I

TOXIC EFFECTS :: Cardiac - pulse rate increase, without fall in BP Endocrine - evidence of thyroid hyperfunction Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1060 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 71 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 26 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg/30D

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 11,403,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84573 No. of Facilities: 83 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 330 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84573 No. of Facilities: 135 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 4095 (estimated) No. of Female Employees: 2136 (estimated)

盐酸硫利达嗪安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335-H410

[ 警示性声明 ]:
P301 + P312 + P330-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R22;R36/37/38;R50/53

[ 安全声明 (欧洲) ]:
S26-S36-S60-S61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ RTECS号 ]:
SP2275000

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盐酸硫利达嗪文献

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Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

Chemotherapeutic efficacy of thioridazine as an adjunct drug in a murine model of latent tuberculosis.

Tuberculosis (Edinb.) 94(6) , 695-700, (2014)

Thioridazine, a potent phenothiazine compound was evaluated for its chemotherapeutic efficacy against experiment model of tuberculosis. Thioridazine potentiated the activities of both isoniazid and ri...

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