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2-亚硝基-1-萘酚

2-亚硝基-1-萘酚用途

1.用于测定钴；锆；铜；铁和钯。也可用于有机合成。

2.用作光度法测定钴、锆等的显色剂。也用作钯等金属离子的萃取剂。还用作有机合成中间体。

2-亚硝基-1-萘酚名称

[ CAS 号 ]:
132-53-6

[ 中文名 ]:
2-亚硝基-1-萘酚

[ 英文名 ]:
2-Nitroso-1-naphthol

[中文别名 ]:

[英文别名 ]:

C.I.Oxidation Base 15
2-nitroso-1-naphtho
1-Naphthalenol, 2-nitroso-
EINECS 205-064-5
2-Nitrosonaphthol
1-hydroxy-2-nitrosonaphthalene
2-Nitroso-1-naphthol
1-Naphthol,2-nitroso
2-nitrosonaphthalen-1-ol
2-Nitroiso-1-Naphthol

2-亚硝基-1-萘酚物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
357.6±25.0 °C at 760 mmHg

[ 熔点 ]:
150-155 °C (dec.)(lit.)

[ 分子式 ]:
C₁₀H₇NO₂

[ 分子量 ]:
173.168

[ 闪点 ]:
170.1±23.2 °C

[ 精确质量 ]:
173.047684

[ PSA ]:
49.66000

[ LogP ]:
2.42

[ 外观性状 ]:
紫色-黄色固体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.630

[ 储存条件 ]:
室温

[ 水溶解性 ]:
SLIGHTLY SOLUBLE

2-亚硝基-1-萘酚MSDS

2-亚硝基-1-萘酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL4550000

CHEMICAL NAME :: 1-Naphthol, 2-nitroso-

CAS REGISTRY NUMBER :: 132-53-6

BEILSTEIN REFERENCE NO. :: 1867919

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H7-N-O2

MOLECULAR WEIGHT :: 173.18

WISWESSER LINE NOTATION :: L66J BQ CNO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,35,1953 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 31 gm/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - testicular tumors

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 41,985,1968

2-亚硝基-1-萘酚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QL4550000

[ 海关编码 ]:
2908999090

2-亚硝基-1-萘酚合成路线

2-亚硝基-1-萘酚制备

生产方法简介

1.由1-萘酚经亚硝化而得。1.亚硝化将氢氧化钠溶于水后，在搅拦下加入1-萘酚。过滤，滤液保持在0-5℃下，加旱灾亚硝酸钠水溶液，加完再慢慢加入乙酸。然后用1：4的稀盐酸调整pH，使刚果红试纸呈蓝色为止。用淀粉碘化钾试纸控制点，继续搅拌半小时，滤出硝化物，水洗至不呈酸性为止，干燥。2.除去异构物亚硝化还生成4-亚硝基-1-萘酚，可用下法除去即把氢氧化钾溶于酒精后，在搅拌下慢慢加入干燥的硝化物，此时反应温度保持在60℃，加毕，继续搅拌10min。冷却，滤出粗品，加入乙醇浸泡，过滤。最后精制即得成品。

2. 搅拌下将α- 萘酚加到氢氧化钠水溶液中，滤去不溶物。控制滤液温度为0～5℃，依次加入亚硝酸钠溶液和醋酸，然后再用1∶ 4的稀盐酸调狆犎值，使刚果红试纸呈蓝色，用淀粉碘化钾试纸控制反应终点。反应结束后继续搅拌半小时，过滤，然后用水洗涤硝化物结晶至不呈酸性，干燥。将干燥的硝化物结晶在搅拌下慢慢地加到氢氧化钾的乙醇溶液中，保持温度为60℃，之后，继续搅拌10min，静置自然冷却，过滤所得结晶用乙醇浸泡后再过滤，以除去异构物将所得结晶溶于热的蒸馏水中，加入活性炭脱色，搅拌下加入盐酸至滤液ph值为5，析出的沉淀用蒸馏水洗涤一次，再用乙醇重结晶，即得成品。
反应过程式为：

2-亚硝基-1-萘酚海关

[ 海关编码 ]: 2908999090

[ 中文概述 ]:
2908999090 其他酚及酚醇的卤化等衍生物（包括其磺化、硝化或亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

2-亚硝基-1-萘酚文献

Oxidative DNA damage induced by a metabolite of 2-naphthylamine, a smoking-related bladder carcinogen.

Jpn. J. Cancer Res. 93 , 736-743, (2002)

2-Naphthylamine (2-NA), a bladder carcinogen, is contained in cigarette smoke. DNA adduct formation is thought to be a major cause of DNA damage by carcinogenic aromatic amines. We have investigated w...

2-Nitroso-1-naphthol as a selective reagent for preconcentration of cobalt by vortex assisted combined with solidification of organic droplet and its determination by flame atomic absorption spectrometry.

Environ. Monit. Assess. 185(11) , 9067-75, (2013)

Highly rapid and selective vortex-assisted liquid-liquid microextraction based on solidification of organic drop has been used for determination of cobalt ion. 2-Nitroso-1-naphthol (2N1N) was used as ...

Separation, preconcentration and inductively coupled plasma-mass spectrometric (ICP-MS) determination of thorium(IV), titanium(IV), iron(III), lead(II) and chromium(III) on 2-nitroso-1-naphthol impregnated MCI GEL CHP20P resin.

J. Hazard. Mater. 173(1-3) , 669-74, (2010)

A simple and effective method is presented for the separation and preconcentration of Th(IV), Ti(IV), Fe(III), Pb(II) and Cr(III) by solid phase extraction on 2-nitroso-1-naphthol impregnated MCI GEL ...

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