邻碘马尿酸钠

邻碘马尿酸钠用途

o-Iodohippurate sodium is an analogue of p-aminohippuric acid for the determination of effective renal plasma flow. Labelled OIH has a significantly higher clearance than other radiopharmaceutical yet developed and is eminently suitable for renography. It is eliminated mainly by tubular secretion. In patients with normally functioning kidneys, 85% of the OIH may be found in the urine 30 minutes after intravenous injection.

邻碘马尿酸钠名称

[ CAS 号 ]:
133-17-5

[ 中文名 ]:
邻碘马尿酸钠

[ 英文名 ]:
o-Iodohippurate sodium

[英文别名 ]:

hippuran
jodairol
iodohippura
medopaque
Sodium iodohippurate
EINECS 205-097-5
iodairal
renumbral
orthoiodin
iodohippuratesodium

邻碘马尿酸钠物理化学性质

[ 沸点 ]:
480.9ºC at 760mmHg

[ 分子式 ]:
C₉H₇INNaO₃

[ 分子量 ]:
327.05100

[ 闪点 ]:
244.6ºC

[ 精确质量 ]:
326.93700

[ PSA ]:
69.23000

[ LogP ]:
0.16180

[ 蒸汽压 ]:
4.67E-10mmHg at 25°C

邻碘马尿酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MR8162000

CHEMICAL NAME :: Hippuric acid, o-iodo-, monosodium salt

CAS REGISTRY NUMBER :: 133-17-5

LAST UPDATED :: 199309

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H7-I-N-O3.Na

MOLECULAR WEIGHT :: 327.06

WISWESSER LINE NOTATION :: OVIMVR BI &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 116,394,1956

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 42,721,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MECHAN Medicinal Chemistry, A Series of Reviews. (New York, NY) V.1-6, 1951-63. Discontinued. Volume(issue)/page/year: 6,290,1963