C: DGLU-ALA-ALLO-DILE-LEU-DTRP

C: DGLU-ALA-ALLO-DILE-LEU-DTRP名称

[ CAS 号 ]:
136553-74-7

[ 中文名 ]:
C: DGLU-ALA-ALLO-DILE-LEU-DTRP

[ 英文名 ]:
BE-18257B

C: DGLU-ALA-ALLO-DILE-LEU-DTRP物理化学性质

[ 密度 ]:
1.23g/cm3

[ 沸点 ]:
1012.2ºC at 760 mmHg

[ 分子式 ]:
C₃₁H₄₄N₆O₇

[ 分子量 ]:
612.71700

[ 闪点 ]:
566ºC

[ 精确质量 ]:
612.32700

[ PSA ]:
198.59000

[ LogP ]:
2.76890

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.574

C: DGLU-ALA-ALLO-DILE-LEU-DTRPMSDS

详细MSDS(安全技术说明书)

C: DGLU-ALA-ALLO-DILE-LEU-DTRP毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GT9160000

CHEMICAL NAME :: Cyclo(L-alanyl-D-alloisoleucyl-L-leucyl-D-tryptophyl- D-alpha-glutamyl)

CAS REGISTRY NUMBER :: 136553-74-7

LAST UPDATED :: 199303

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C31-H44-N6-O7

MOLECULAR WEIGHT :: 612.81

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 44,1342,1991

C: DGLU-ALA-ALLO-DILE-LEU-DTRP安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
GT9160000

C: DGLU-ALA-ALLO-DILE-LEU-DTRP文献

An endothelin receptor (ETA) antagonist isolated from Streptomyces misakiensis.

Biochem. Biophys. Res. Commun. 178 , 132, (1991)

A competitive endothelin (ET) antagonist, BE-18257B, was isolated from the fermentation products of Streptomyces misakiensis. It is a novel cyclic pentapeptide, cyclo(-D-Glu-L-Ala-allo-D-Ile-L-Leu-D-T...

[Agonists and antagonists to endothelin receptors].

Tanpakushitsu Kakusan Koso. 38(11) , 1827-40, (1993)

Effects of endothelin-1 and endothelin-A receptor antagonist on recovery after hypothermic cardioplegic ischemia in neonatal lamb hearts.

Circulation 92(9 Suppl) , II400-4, (1995)

Prior studies suggest an important role for coronary endothelium in ischemia/reperfusion (I/R) injury. Decreased endothelial release of the vasodilator nitric oxide occurs after I/R, but the role of t...

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