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吗啉,聚合物结合

吗啉,聚合物结合用途

吗啉作为医药中间体可溶于合成硝呋复啉（Nifurfoline）,此外以吗啉为基础原料可合成数十药物的中间体,如羟乙基吗啉、吗啉甲酰氯、氨基吗啉和甲基吗啉等。吗啉不仅广泛应用于药物有合成,而且也是用途极广的染料和农药中间体。

吗啉,聚合物结合名称

[ CAS 号 ]:
138048-80-3

[ 中文名 ]:
吗啉

[ 英文名 ]:
StratoSpheres PL-MPH resin

[英文别名 ]:

MFCD01867502

吗啉,聚合物结合物理化学性质

[ 分子式 ]:
C₂₉H₃₃NO

[ 分子量 ]:
411.58

[ 外观性状 ]:
macroporous

[ 储存条件 ]:
2-8°C

吗啉,聚合物结合安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

吗啉,聚合物结合制备

由二乙醇胺经硫酸脱水环合而得。将二乙醇胺加入水反应锅内，在 60 ℃ 以下滴加硫酸，加毕，升温于185 -195 ℃ ，保温30min。冷至 60 ℃ 以下，滴加氢氧化钠液至pH=11，冷却，过滤，滤液精馏，收集 130 ℃ 以下馏分，精吗啉含量可达99.5%以上。该法原料易得，目前已成为世界生产吗啉的主要方法。由二噁烷与氨气相催化反应而可制得吗啉。

吗啉,聚合物结合文献

Synthesis and antitumor activities of some new N1-(flavon-6-yl)amidrazone derivatives.

Arch. Pharm. (Weinheim) 347(6) , 415-22, (2014)

A new series of N1-(flavon-6-yl)amidrazones were synthesized by reacting the hydrazonoyl chloride derived from 6-aminoflavone with the appropriate sec-cyclic amines. The antitumor activities of these ...

The c-MET/PI3K signaling is associated with cancer resistance to doxorubicin and photodynamic therapy by elevating BCRP/ABCG2 expression.

Mol. Pharmacol. 87(3) , 465-76, (2015)

Overexpression of BCRP/ABCG2, a xenobiotic efflux transporter, is associated with anticancer drug resistance in tumors. Proto-oncogene c-MET induces cancer cell proliferation, motility, and survival, ...

Novel mechanism of hydrogen sulfide-induced guinea pig urinary bladder smooth muscle contraction: role of BK channels and cholinergic neurotransmission.

Am. J. Physiol. Cell Physiol. 309 , C107-16, (2015)

Hydrogen sulfide (H2S) is a key signaling molecule regulating important physiological processes, including smooth muscle function. However, the mechanisms underlying H2S-induced detrusor smooth muscle...

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