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仲丁胺

仲丁胺用途

用作农药、医药和硅氧烷的中间体.

仲丁胺名称

[ CAS 号 ]:
13952-84-6

[ 中文名 ]:
2-氨基丁烷

[ 英文名 ]:
sec-Butylamine

[中文别名 ]:

[英文别名 ]:

(±)-sec-Butylamine
sec-Butylamine
2-Butylamin
MFCD00008094
EINECS 237-732-7
sec-C4H9NH2
(RS)-2-aminobutane
2-AB
2-butanamine
(+/-)-2-Aminobutane

仲丁胺物理化学性质

[ 密度 ]:
0.724 g/mL at 25 °C(lit.)

[ 沸点 ]:
63 °C(lit.)

[ 熔点 ]:
-104 °C

[ 分子式 ]:
C₄H₁₁N

[ 分子量 ]:
73.13680

[ 闪点 ]:
−3 °F

[ 精确质量 ]:
73.08910

[ PSA ]:
26.02000

[ LogP ]:
1.44390

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
175mmHg at 25°C

[ 折射率 ]:
n20/D 1.3928(lit.)

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸,食品原料类分开存放

[ 稳定性 ]:
Stable, but light sensitive. Incompatible with strong oxidizing agents, strong acids. Highly flammable.

[ 水溶解性 ]:
MISCIBLE

仲丁胺MSDS

详细MSDS(安全技术说明书)

仲丁胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EO3325000

CHEMICAL NAME :: sec-Butylamine

CAS REGISTRY NUMBER :: 13952-84-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C4-H11-N

MOLECULAR WEIGHT :: 73.16

WISWESSER LINE NOTATION :: ZY2&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 152 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Behavioral - antipsychotic Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 63,150,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,112,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,112,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,112,1991 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-DENMARK:STEL 5 ppm (15 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 5 ppm (15 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (15 mg/m3);STEL 25 ppm (75 mg/m3) JAN 1993

仲丁胺安全信息

[ 符号 ]:

GHS02, GHS05, GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301-H314-H332-H410

[ 警示性声明 ]:
P210-P273-P280-P301 + P310-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R11;R20/22;R35;R50

[ 安全声明 (欧洲) ]:
S9-S16-S26-S28-S36/37/39-S45-S61-S28A

[ 危险品运输编码 ]:
UN 2733 3/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
EO3325000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
29211980

仲丁胺制备

通常由甲乙酮与氨催化加氢反应而得，有常压法和高压法两种工艺。
1、常压法
采用Ni-Cr-HPO3催化剂，在115℃、空速0.15h_-1，原料甲乙酮：氨：氢气=1：4.5：3.5的条件下连续反应生产仲丁胺，收率和选择性分别为99%和93.3%以上。

2、高压法
将甲乙酮和镍催化加入高压釜内，抽出空气后加入液氨，然后升温至160℃(此时压力达3.92MPa)，再加氢至5.88MPa反应10h，期间共加氢3次。冷却至室温出料，除去废镍粉，加人40%的硫酸(温度不超过30℃)。先以水蒸气蒸馏除去仲丁醇，然后减压浓缩脱水得粗品，最后分流精制，收集62~63℃的馏分即为成品。此法生产路线短，原料易得，产品收率高，但需高压。

精制方法：仲丁胺是用丁酮在镍催化剂存在下与氨反应，或用碱金属作催化剂，使2-丁烯发生胺化作用制备的。因此，常含有未反应物与其他的胺类杂质。可加金属钠分馏精制。为了从外消旋体中得到d-异构体，可将仲丁胺制成d-酒石酸盐，进行分步结晶。再用氢氧化钠或氢氧化钾使d-异构体游离出来。仲丁胺的l-异构体可从过滤d-酒石酸盐的滤液中游离出来，再制成l-酒石酸盐的晶体。处理方法和d-异构体相同。

仲丁胺海关

[ 海关编码 ]: 29211980

仲丁胺