4-氯-DL-苯丙氨酸甲酯盐酸盐

4-氯-DL-苯丙氨酸甲酯盐酸盐用途

PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) 是一种可逆的色氨酸羟化酶 (tryptophan hydroxylase) 抑制剂,是 5-羟色胺 (5-HT) 合成抑制剂。PCPA methyl ester hydrochloride 可穿过血脑屏障,并降低 5-HT 的中枢利用率。

4-氯-DL-苯丙氨酸甲酯盐酸盐名称

[ CAS 号 ]:
14173-40-1

[ 中文名 ]:
4-氯-DL-苯基丙氨酸甲酯盐酸盐

[ 英文名 ]:
PCPA methyl ester hydrochloride

[中文别名 ]:

[英文别名 ]:

4-Chloro-DL-Phe-OMe HCl
MFCD00012530
UNII:OC0YKX1H41
EINECS 238-024-0
H-DL-Phe(4-Cl)-OMe.HCl

4-氯-DL-苯丙氨酸甲酯盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 色氨酸羟化酶

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

[ 靶点 ]

serotonin

Tryptophan Hydroxylase

[体内研究]

PCPA甲酯盐酸盐(250-500 mg/kg；口服给药；每天；治疗8周后,海马和皮层的5-羟色胺水平显著降低[3]。在C57BL/6精英雄性小鼠中,口服或ip PCPA甲酯盐酸盐治疗的小鼠海马中的5-HT水平分别降低了85%和55%,而在前额叶皮质中,5-HT水平降低了65%(口服)和50%(ip)[3]。动物模型：C57BL/6精英雄性小鼠(3月龄)[3]剂量：治疗前2天每天500mg/kg,其余时间每天250mg/kg给药：口服；每天；8周后结果：海马和皮层5-羟色胺水平均显著降低。

[参考文献]

[1]. Dool-Ri Oh, et al. Sedative and hypnotic effects of Vaccinium bracteatum Thunb. through the regulation of serotonegic and GABA A-ergic systems: Involvement of 5-HT 1A receptor agonistic activity. Biomed Pharmacother. 2019 Jan;109:2218-2227.

[2]. Fabio Bellia, et al. Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice. Psychopharmacology (Berl). 2021 Jan;238(1):215-225.

[3]. ocío B Foltran, et al. Neurochemical, Behavioral, and Neurogenic Validation of a Hyposerotonergic Animal Model by Voluntary Oral Consumption of para-Chlorophenylalanine. ACS Chem Neurosci. 2020 Mar 18;11(6):952-959.

4-氯-DL-苯丙氨酸甲酯盐酸盐物理化学性质

[ 沸点 ]:
296.3ºC at 760 mmHg

[ 熔点 ]:
186-189 °C(lit.)

[ 分子式 ]:
C₁₀H₁₃Cl₂NO₂

[ 分子量 ]:
250.122

[ 闪点 ]:
133ºC

[ 精确质量 ]:
249.032333

[ PSA ]:
52.32000

[ LogP ]:
2.88510

[ 外观性状 ]:
白色至灰白色粉末

[ 储存条件 ]:
−20°C

4-氯-DL-苯丙氨酸甲酯盐酸盐MSDS

详细MSDS(安全技术说明书)

4-氯-DL-苯丙氨酸甲酯盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY4452100

CHEMICAL NAME :: Alanine, 3-(p-chlorophenyl)-, methyl ester, hydrochloride, DL-

CAS REGISTRY NUMBER :: 14173-40-1

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H12-Cl-N-O2.Cl-H

MOLECULAR WEIGHT :: 250.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 400 mg/kg

SEX/DURATION :: male 4 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 166,1433,1969

4-氯-DL-苯丙氨酸甲酯盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AY4452100

[ 海关编码 ]:
2922499990

4-氯-DL-苯丙氨酸甲酯盐酸盐合成路线

详细合成路线

4-氯-DL-苯丙氨酸甲酯盐酸盐上下游产品

4-氯-DL-苯丙氨酸甲酯盐酸盐上游产品

4-氯-DL-苯丙氨酸甲酯盐酸盐下游产品

4-氯-DL-苯丙氨酸甲酯盐酸盐海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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