Morphinan-3,6-diol,4,5-epoxy-17-methyl-, hydrochloride, (5a,6a)- (9CI)
名称
[ CAS 号 ]:
1421-28-9
[ 英文名 ]:
Morphinan-3,6-diol,4,5-epoxy-17-methyl-, hydrochloride, (5a,6a)- (9CI)
[英文别名 ]:
- Dihydromorphine hydrochloride
- Morphine,dihydro-,hydrochloride
- morphine hydrochloride
物理化学性质
[ 沸点 ]:
475.4ºC at 760mmHg
[ 分子式 ]:
C17H22ClNO3
[ 分子量 ]:
323.81400
[ 闪点 ]:
241.3ºC
[ 精确质量 ]:
323.12900
[ PSA ]:
52.93000
[ LogP ]:
2.16200
[ 蒸汽压 ]:
7.65E-10mmHg at 25°C
毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QD4200000
- CHEMICAL NAME :
- Morphine, dihydro-, hydrochloride
- CAS REGISTRY NUMBER :
- 1421-28-9
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C17-H21-N-O3.Cl-H
- MOLECULAR WEIGHT :
- 323.85
- WISWESSER LINE NOTATION :
- T B6566 B6/CO 4ABBC R BX HO PN GHT&&TTJ EQ JQ P1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 149 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 52,468,1934
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 186 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 66,182,1939
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
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